Long‐term behavioral and pharmacodynamic effects of delta‐9‐tetrahydrocannabinol in female rats depend on ovarian hormone status
- P. Winsauer, J. Daniel, J. L. Sutton
- Biology, PsychologyAddiction Biology
- 1 January 2011
Chronic administration of Δ9‐THC during adolescence in female rats produced long‐term effects on operant learning and performance tasks and on the cannabinoid system that were mediated by the presence of ovarian hormones, and that altered their sensitivity to Δ9-THC as adults.
Ovarian hormones and chronic administration during adolescence modify the discriminative stimulus effects of delta-9-tetrahydrocannabinol (Δ9-THC) in adult female rats
- P. Winsauer, C. Filipeanu, Evangeline M Bailey, J. L. Hulst, J. L. Sutton
- Biology, PsychologyPharmacology, Biochemistry and Behavior
- 1 September 2012
The kainate receptor antagonist 2S,4R-4-methylglutamate attenuates mechanical allodynia and thermal hyperalgesia in a rat model of nerve injury
- J. L. Sutton, M. Maccecchini, K. Kajander
- BiologyNeuroscience
- 1 June 1999
Hormonal status and age differentially affect tolerance to the disruptive effects of delta-9-tetrahydrocannabinol (Δ9-THC) on learning in female rats
- P. Winsauer, C. Filipeanu, Peter F. Weed, J. L. Sutton
- Biology, PsychologyFrontiers in Pharmacology
- 2 July 2015
Hormone status differentially affects the development of tolerance to the disruptive effects of delta-9-tetrahydrocannabinol (Δ9-THC) on learning and performance behavior in adolescent, but not adult, female rats.
Chronic administration during early adulthood does not alter the hormonally-dependent disruptive effects of delta-9-tetrahydrocannabinol (Δ9-THC) on complex behavior in female rats
- P. Winsauer, J. L. Sutton
- Psychology, BiologyPharmacology, Biochemistry and Behavior
- 1 February 2014
The interaction of chronic delta‐9‐tetrahydrocannabinol (THC) and estradiol during early adulthood has long‐term effects on learning in female rats
- P. Winsauer, J. L. Sutton
- Psychology, Biology
- 1 April 2010
It is indicated that chronic THC in female rats during early adulthood, as well as adolescence, can have long‐term, hormonally‐dependent effects on learning, and that these effects show only moderate age sensitivity.
The interaction of delta‐9‐tetrahydrocannabinol (THC) and estradiol during adolescence has long‐term effects on the repeated acquisition and performance of response sequences in female rats
- J. L. Sutton, J. L. Hulst, P. Winsauer
- Psychology, Biology
- 1 April 2009
The results indicate that adolescent THC administration in female rats can have long‐term effects on their capacity to learn, and that these effects cannot be readily predicted from the effects of THC on response rate or on performance tasks.