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Excitatory cortical neurons form fine-scale functional networks
The specificity of cortical neuron connections creates columns of functionally similar neurons spanning from the pia to the white matter. Here we investigate whether there is an additional, finerExpand
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Laminar sources of synaptic input to cortical inhibitory interneurons and pyramidal neurons
The functional role of an individual neuron within a cortical circuit is largely determined by that neuron's synaptic input. We examined the laminar sources of local input to subtypes of corticalExpand
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Specific Polyunsaturated Fatty Acids Drive TRPV-Dependent Sensory Signaling In Vivo
A variety of lipid and lipid-derived molecules can modulate TRP cation channel activity, but the identity of the lipids that affect TRP channel function in vivo is unknown. Here, we use genetic andExpand
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Brominated 7-hydroxycoumarin-4-ylmethyls: photolabile protecting groups with biologically useful cross-sections for two photon photolysis.
Photochemical release (uncaging) of bioactive messengers with three-dimensional spatial resolution in light-scattering media would be greatly facilitated if the photolysis could be powered by pairsExpand
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The Development of Local, Layer-Specific Visual Cortical Axons in the Absence of Extrinsic Influences and Intrinsic Activity
The laminar specificity of vertical connections in the primary visual cortex (area 17) develops precisely from the outset, leading to the hypothesis that layer-specific axonal targeting isExpand
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Properties of Ectopic Neurons Induced byXenopusNeurogenin1 Misexpression
We have examined cells cultured from ectoderm-misexpressing Neurogenin1 (Ngn1) to describe better the extent to which this gene can control aspects of neuronal phenotype including motility,Expand
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Development of visual cortical axons: Layer‐specific effects of extrinsic influences and activity blockade
During normal cortical development, individual pyramidal neurons form intracortical axonal arbors that are specific for particular cortical layers. Pyramidal neurons within layer 6 are able toExpand
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Topographic specificity of functional connections from hippocampal CA3 to CA1.
The hippocampus is a cortical region thought to play an important role in learning and memory. Most of our knowledge about the detailed organization of hippocampal circuitry responsible for theseExpand
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Supplemental Experimental Procedures Strains
bated at 80°C for 1 hr. After the addition of 0.2 mL of hexane and 1.5 mL H2O, the fatty acid methyl esters were extracted into the hexane layer by shaking and centrifuging the tubes at low speed.Expand