• Publications
  • Influence
Adenosine A1 receptor down‐regulation in mothers and fetal brain after caffeine and theophylline treatments to pregnant rats
Pregnant rats were treated daily with 1 g/L of caffeine or theophylline in their drinking water during pregnancy and the effect of these methylxanthines on adenosine A1 receptor was assayed usingExpand
  • 70
  • 4
Impaired metabotropic glutamate receptor/phospholipase C signaling pathway in the cerebral cortex in Alzheimer's disease and dementia with Lewy bodies correlates with stage of
The aim of the present work was to analyze the status of metabotropic glutamate receptors (mGluRs) in the frontal cortex (area 8) from ten cases with common form DLB (cDLB) and eleven cases with pureExpand
  • 90
  • 2
Increased 5-Methylcytosine and Decreased 5-Hydroxymethylcytosine Levels are Associated with Reduced Striatal A2AR Levels in Huntington’s Disease
Adenosine A2A receptor (A2AR) is a G-protein-coupled receptor highly expressed in basal ganglia. Its expression levels are severely reduced in Huntington’s disease (HD), and several pharmacologicalExpand
  • 98
  • 2
Membrane cholesterol access into a G-protein-coupled receptor
Cholesterol is a key component of cell membranes with a proven modulatory role on the function and ligand-binding properties of G-protein-coupled receptors (GPCRs). Crystal structures of prototypicalExpand
  • 71
  • 2
  • PDF
Maternal caffeine intake during gestation and lactation down‐regulates adenosine A1 receptor in rat brain from mothers and neonates
Even though caffeine can be excreted in breast milk, few studies have analyzed the effect of maternal caffeine consumption during lactation on neonatal brain. In the present work pregnant rats wereExpand
  • 27
  • 2
Abnormal Group I Metabotropic Glutamate Receptor Expression and Signaling in the Frontal Cortex in Pick Disease
Group I metabotropic glutamate receptors (mGluR1) regulate synaptic transmission through the stimulation of phospholipase Cβ1 (PLCβ1) and then by the activation of protein kinase C (PKC). ConsideringExpand
  • 25
  • 2
Chronic intake of caffeine during gestation down regulates metabotropic glutamate receptors in maternal and fetal rat heart
Summary.Caffeine is the most widely consumed substance in the world which antagonizes adenosine effects. Adenosine acting through A1 receptors inhibits glutamate release which binds to metabotropicExpand
  • 18
  • 2
RESEARCH ARTICLE: Up‐regulation of Adenosine Receptors in the Frontal Cortex in Alzheimer's Disease
Adenosine receptors are G‐protein coupled receptors which modulate neurotransmitter release, mainly glutamate. Adenosine A1 and A2A receptors were studied in post‐mortem human cortex in Alzheimer'sExpand
  • 117
  • 1
Age-related expression of adenosine receptors in brain from the senescence-accelerated mouse
Senescence-accelerated mice (SAM) are used as a model of aging and age-associated diseases. SAMP8 are prone strains that show shortened life span and deficits in learning and memory processes, whileExpand
  • 30
  • 1
  • PDF
Abnormal Metabotropic Glutamate Receptor Expression and Signaling in the Cerebral Cortex in Diffuse Lewy Body Disease is Associated with Irregular α‐Synuclein/Phospholipase C (PLCβ1) Interactions
Diffuse Lewy body disease (DLBD) is a degenerative disease of the nervous system, involving the brain stem, diencephalic nuclei and cerebral cortex, associated with abnormal α‐synuclein aggregationExpand
  • 62
  • 1