Regulation of Synaptic Efficacy by Coincidence of Postsynaptic APs and EPSPs
In dual whole-cell voltage recordings from pyramidal neurons, the coincidence of post Synaptic action potentials and unitary excitatory postsynaptic potentials was found to induce changes in EPSPs.
Physiology and anatomy of synaptic connections between thick tufted pyramidal neurones in the developing rat neocortex.
Dual voltage recordings were made from pairs of adjacent, synaptically connected thick tufted layer 5 pyramidal neurones in brain slices of young rat (14‐16 days) somatosensory cortex to examine the physiological properties of unitary EPSPs and the axonal and dendritic anatomy of both projecting and target neurones was uniform.
Importance of AMPA receptors for hippocampal synaptic plasticity but not for spatial learning.
The results suggest that CA1 hippocampal LTP is controlled by the number or subunit composition of AMPA receptors and show a dichotomy between LTP in CA1 and acquisition of spatial memory.
Reliable synaptic connections between pairs of excitatory layer 4 neurones within a single ‘barrel’ of developing rat somatosensory cortex
The results suggest that in L4 of the barrel cortex synaptic transmission between spiny neurones is largely restricted to a single barrel and the connections are very reliable, probably due to a high release probability, and have a high efficacy because of the compact structure of the dendrites and axons of spiny neurons.
Synaptic connections between layer 4 spiny neurone‐ layer 2/3 pyramidal cell pairs in juvenile rat barrel cortex: physiology and anatomy of interlaminar signalling within a cortical column
The results suggest that each connected L4 spiny neurone produces a weak but reliable EPSP in the pyramidal cell, implying that transmission of signals to layer 2/3 is likely to have a high threshold requiring simultaneous activation of many L4 neurons, and postsynaptic glutamate receptors act as a gate for the lateral spread of excitation in layer 1/3.
Efficacy and connectivity of intracolumnar pairs of layer 2/3 pyramidal cells in the barrel cortex of juvenile rats
Synaptically coupled layer 2/3 pyramidal neurones located above the same layer 4 barrel (‘barrel‐related’) were investigated using dual whole‐cell voltage recordings in acute slices of rat somatosensory cortex, suggesting that synchronous feed‐forward excitation of L2/3Pyramidal cells arriving from layer 4 could be potentially amplified in layer 1/3 by feedback excitation within a column and then relayed to the neighbouring columns.
Three-Dimensional Reconstruction of a Calyx of Held and Its Postsynaptic Principal Neuron in the Medial Nucleus of the Trapezoid Body
The geometry of the reconstructed synapse suggests that each of the hundreds of SCs is likely to contribute independently to the size and rising phase of the EPSC during a single AP.
Submillisecond AMPA Receptor-Mediated Signaling at a Principal Neuron–Interneuron Synapse
Columnar Organization of Dendrites and Axons of Single and Synaptically Coupled Excitatory Spiny Neurons in Layer 4 of the Rat Barrel Cortex
The largely columnar organization of dendrites and axons of both cell types, combined with the preferential and dense projections within cortical layers 4 and 2/3, suggests that spiny stellate and star pyramidal neurons of layer 4 serve to amplify thalamic input and relay excitation vertically within a single cortical column.
Pyramidal neurons in layer 5 of the rat visual cortex. I. Correlation among cell morphology, intrinsic electrophysiological properties, and axon targets
- E. Kasper, A. Larkman, J. Lübke, C. Blakemore
- BiologyThe Journal of comparative neurology
- 22 January 1994
The present study combined intracellular recording in isolated slices of rat visual cortex and injection of carboxyfluorescein, to reveal soma‐dendritic morphology, with prior injection of rhodamine‐conjugated microspheres into the superior colliculus or contralateral visual cortex to label neurons according to the target of the superiorColliculus, implying that the majority of such cells project to that target.