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Biological Insights From 108 Schizophrenia-Associated Genetic Loci
TLDR
Associations at DRD2 and several genes involved in glutamatergic neurotransmission highlight molecules of known and potential therapeutic relevance to schizophrenia, and are consistent with leading pathophysiological hypotheses. Expand
Lifetime prevalence of psychotic and bipolar I disorders in a general population.
TLDR
The use of comprehensive methods reveals that their lifetime prevalence exceeds 3%, and multiple sources of information are essential for accurate estimation of lifetime prevalences of psychotic disorders. Expand
Genome-wide association study identifies five new schizophrenia loci
TLDR
The role of common genetic variation in schizophrenia in a genome-wide association study of substantial size is examined, suggesting MIR137-mediated dysregulation as a previously unknown etiologic mechanism in schizophrenia. Expand
DSM-IV mood-, anxiety- and alcohol use disorders and their comorbidity in the Finnish general population
TLDR
Mental disorders and their comorbidities are distributed unevenly between sexes and age groups, are particularly associated with marital and employment status, and vary by region. Expand
Genome scan meta-analysis of schizophrenia and bipolar disorder, part II: Schizophrenia.
TLDR
The GSMA produced significant genomewide evidence for linkage on chromosome 2q and suggests that some or all of these regions contain loci that increase susceptibility to schizophrenia in diverse populations. Expand
Genetic influences on brain structure
TLDR
Detailed three-dimensional maps revealing how brain structure is influenced by individual genetic differences are reported, and may shed light on the heritability of cognitive and linguistic skills, as well as genetic liability for diseases that affect the human cortex. Expand
11-year follow-up of mortality in patients with schizophrenia: a population-based cohort study (FIN11 study)
TLDR
Although the proportional use of second-generation antipsychotic drugs rose from 13% to 64% during follow-up, the gap in life expectancy between patients with schizophrenia and the general population did not widen between 1996 and 2006. Expand
Specific developmental disruption of disrupted-in-schizophrenia-1 function results in schizophrenia-related phenotypes in mice
TLDR
It is demonstrated that early postnatal, but not adult induction, of a C-terminal portion of DISC1 in mice results in a cluster of schizophrenia-related phenotypes, including reduced hippocampal dendritic complexity, depressive-like traits, abnormal spatial working memory, and reduced sociability. Expand
Mental disorders and comorbidity in suicide.
TLDR
The majority of suicide victims suffered from comorbid mental disorders, and needs to be taken into account when analyzing the relationship between suicide and mental disorders and in planning treatment strategies for suicide prevention in clinical practice. Expand
The relationship between job-related burnout and depressive disorders--results from the Finnish Health 2000 Study.
TLDR
The concepts of burnout and depression complement each other and cover partly overlapping phenomena and are related to job-related burnout, particularly when it is severe. Expand
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