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Biological Insights From 108 Schizophrenia-Associated Genetic Loci
Associations at DRD2 and several genes involved in glutamatergic neurotransmission highlight molecules of known and potential therapeutic relevance to schizophrenia, and are consistent with leading pathophysiological hypotheses.
Lifetime prevalence of psychotic and bipolar I disorders in a general population.
The use of comprehensive methods reveals that their lifetime prevalence exceeds 3%, and multiple sources of information are essential for accurate estimation of lifetime prevalences of psychotic disorders.
Genome-wide association study identifies five new schizophrenia loci
The role of common genetic variation in schizophrenia in a genome-wide association study of substantial size is examined, suggesting MIR137-mediated dysregulation as a previously unknown etiologic mechanism in schizophrenia.
Genome scan meta-analysis of schizophrenia and bipolar disorder, part II: Schizophrenia.
The GSMA produced significant genomewide evidence for linkage on chromosome 2q and suggests that some or all of these regions contain loci that increase susceptibility to schizophrenia in diverse populations.
DSM-IV mood-, anxiety- and alcohol use disorders and their comorbidity in the Finnish general population
- S. Pirkola, E. Isometsä, J. Lönnqvist
- Medicine, PsychologySocial Psychiatry and Psychiatric Epidemiology
Mental disorders and their comorbidities are distributed unevenly between sexes and age groups, are particularly associated with marital and employment status, and vary by region.
Genetic influences on brain structure
Detailed three-dimensional maps revealing how brain structure is influenced by individual genetic differences are reported, and may shed light on the heritability of cognitive and linguistic skills, as well as genetic liability for diseases that affect the human cortex.
11-year follow-up of mortality in patients with schizophrenia: a population-based cohort study (FIN11 study)
The UK10K project identifies rare variants in health and disease
- Klaudia Josine L. Jie Lucy Yasin Shane John R. B. ChangJia Walter Min Huang Crooks Memari McCarthy Perry Xu F, Klaudia Walter, Weihua Zhang
- 14 September 2015
In extensively phenotyped cohorts, insights from sequencing whole genomes or exomes of nearly 10,000 individuals from population-based and disease collections are described and population structure and functional annotation of rare and low-frequency variants are described.
Mental disorders and comorbidity in suicide.
- M. Henriksson, H. Aro, J. Lönnqvist
- Psychology, MedicineThe American journal of psychiatry
- 1 June 1993
The majority of suicide victims suffered from comorbid mental disorders, and needs to be taken into account when analyzing the relationship between suicide and mental disorders and in planning treatment strategies for suicide prevention in clinical practice.