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Mesuol, a natural occurring 4-phenylcoumarin, inhibits HIV-1 replication by targeting the NF-kappaB pathway.
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Preliminary study of the anti-inflammatory activity of hexane extract and fractions from Bursera simaruba (Linneo) Sarg. (Burseraceae) leaves.
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Synthesis and antimitotic and tubulin interaction profiles of novel pinacol derivatives of podophyllotoxins.
TLDR
Significantly, 7α-isopropyl-7-deoxypodophyllotoxin (20), without any hydroxyl function, appeared as a promising lead compound for a novel type of tubulin polymerization inhibitors.
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3-Phenylcoumarins as Inhibitors of HIV-1 Replication
TLDR
The antiviral effect of the 4-hydroxycoumarin derivative 19 correlates with its specific inhibition of Tat functions, while compound 8, 3-(2-chlorophenyl)cou marin, seems to act through a mechanism unrelated to the molecular targets considered in this research.
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Vasorelaxant activity of phthalazinones and related compounds.
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Analgesic-antiinflammatory properties of Proustia pyrifolia.
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Leishmanicidal and trypanocidal activities of 2-aminocyclohexanol and 1,2-cyclohexanediamine derivatives.
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Vasoactive effects of different fractions from two Panamanians plants used in Amerindian traditional medicine.
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Uprolides N, O and P from the Panamanian Octocoral Eunicea succinea
TLDR
Three new diterpenes were isolated from the CH2Cl2-MeOH extract of the gorgonian octocoral Eunicea succinea, collected from Bocas del Toro, on the Caribbean coast of Panama, and displayed anti-inflammatory properties by inhibiting production of Tumor Necrosis Factor and Interleukin induced by lipopolysaccharide (LPS) in murine macrophages.
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Triterpenes from Warszewiczia coccinea (Rubiaceae) as Inhibitors of Acetylcholinesterase
Seventy-six plant extracts from the Panamanian flora have been screened for acetylcholinesterase (AChE) inhibitors by thin-layer chromatography (TLC) bioautography. The most promising extracts with…
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