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The Elongator subcomplex Elp456 is a hexameric RecA-like ATPase
Elongator was initially described as an RNA polymerase II–associated factor but has since been associated with a broad range of cellular activities. It has also attracted clinical attention becauseExpand
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Structural and functional studies of Bud23–Trm112 reveal 18S rRNA N7-G1575 methylation occurs on late 40S precursor ribosomes
Significance Ribosomes are essential cellular nanomachines responsible for all protein synthesis in vivo. Efficient and faithful ribosome biogenesis requires a plethora of assembly factors whoseExpand
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Insights into molecular plasticity in protein complexes from Trm9-Trm112 tRNA modifying enzyme crystal structure
Most of the factors involved in translation (tRNA, rRNA and proteins) are subject to post-transcriptional and post-translational modifications, which participate in the fine-tuning and tight controlExpand
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Trm112, a Protein Activator of Methyltransferases Modifying Actors of the Eukaryotic Translational Apparatus
Post-transcriptional and post-translational modifications are very important for the control and optimal efficiency of messenger RNA (mRNA) translation. Among these, methylation is the mostExpand
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Evolutionary insights into Trm112-methyltransferase holoenzymes involved in translation between archaea and eukaryotes
Abstract Protein synthesis is a complex and highly coordinated process requiring many different protein factors as well as various types of nucleic acids. All translation machinery components requireExpand
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Systematic bioinformatics and experimental validation of yeast complexes reduces the rate of attrition during structural investigations.
For high-throughput structural studies of protein complexes of composition inferred from proteomics data, it is crucial that candidate complexes are selected accurately. Herein, we exemplify aExpand
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Structure-function analysis of Sua5 protein reveals novel functional motifs required for the biosynthesis of the universal t6A tRNA modification.
N6-threonyl-carbamoyl adenosine (t6A) is a universal tRNA modification found at position 37, next to the anticodon, in almost all tRNAs decoding ANN codons (where N = A, U, G, or C). t6A stabilizesExpand
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Structural insight into the formation of lipoprotein-β-barrel complexes by the β-barrel assembly machinery
The β-barrel assembly machinery (BAM) inserts outer membrane β-barrel proteins (OMPs) in the outer membrane of Gram-negative bacteria. In Enterobacteriacea, BAM also mediates export of the stressExpand
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Structure-function analysis of Sua 5 protein reveals novel functional motifs required for the biosynthesis of the universal t 6 A tRNA modification
N-threonyl-carbamoyl adenosine (tA) is a universal tRNA modification found at position 37, next to the anticodon, in almost all tRNAs decoding ANN codons (where N = A, U, G, or C). tA stabilizes theExpand
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