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Costimulation Blockade Alters Germinal Center Responses and Prevents Antibody‐Mediated Rejection
De novo donor‐specific antibody (DSA) after organ transplantation promotes antibody‐mediated rejection (AMR) and causes late graft loss. Previously, we demonstrated that depletion using anti‐CD3Expand
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Unique aspects of rejection and tolerance in liver transplantation.
Spontaneous acceptance of liver allografts occurs in several species. However, tolerance is rare in human transplant patients even though rejection is relatively easily reversed. HistologicalExpand
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Surveillance of Acute Rejection in Baboon Renal Transplantation by Elevation of Interferon-&ggr; Inducible Protein-10 and Monokine Induced by Interferon-&ggr; in Urine
Background. CXCR3 binding chemokines play a key role in recruitment of inflammatory cells into an organ transplant. This study addresses the question of whether urinary excretion of these chemokinesExpand
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Noninvasive Detection of Acute and Chronic Injuries in Human Renal Transplant by Elevation of Multiple Cytokines/Chemokines in Urine
Background. Injuries in kidney transplant is currently diagnosed by needle biopsy. A noninvasive test that sensitively detects these injuries would benefit the patients. Methods. Urine samples wereExpand
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Crosstalk Between T and B Cells in the Germinal Center After Transplantation.
Crosstalk between B and T cells in transplantation is increasingly recognized as being important in the alloimmune response. T cell activation of B cells occurs by a 3-stage pathway, culminating withExpand
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Enhanced De Novo Alloantibody and Antibody‐Mediated Injury in Rhesus Macaques
Chronic allograft rejection is a major impediment to long‐term transplant success. Humoral immune responses to alloantigens are a growing clinical problem in transplantation, with mounting evidenceExpand
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Immunothrombotic Activity of Damage-Associated Molecular Patterns and Extracellular Vesicles in Secondary Organ Failure Induced by Trauma and Sterile Insults
Despite significant improvements in injury prevention and emergency response, injury-related death and morbidity continues to increase in the US and worldwide. Patients with trauma, invasiveExpand
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The role of B cells in solid organ transplantation.
The role of antibodies in chronic injury to organ transplants has been suggested for many years, but recently emphasized by new data. We have observed that when immunosuppressive potency decreasesExpand
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Lymphodepletional strategies in transplantation.
Because lymphocytes were shown to mediate transplant rejection, their depletion has been studied as a mechanism of preventing rejection and perhaps inducing immunologic tolerance. Agents thatExpand
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Patterns of De Novo Allo B Cells and Antibody Formation in Chronic Cardiac Allograft Rejection After Alemtuzumab Treatment
Even though the etiology of chronic rejection (CR) is multifactorial, donor specific antibody (DSA) is considered to have a causal effect on CR development. Currently the antibody‐mediated mechanismsExpand
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