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AIF suppresses chemical stress‐induced apoptosis and maintains the transformed state of tumor cells
Apoptosis‐inducing factor (AIF) exhibits reactive oxygen species (ROS)‐generating NADH oxidase activity of unknown significance, which is dispensable for apoptosis. We knocked out the aif gene in twoExpand
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The smoking-associated oxidant hypothiocyanous acid induces endothelial nitric oxide synthase dysfunction.
Smokers have an elevated risk of cardiovascular disease but the origin(s) of this increased risk are incompletely defined. Considerable evidence supports an accumulation of the oxidant-generatingExpand
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Critical role of the STAT3 pathway in the cardioprotective efficacy of zoniporide in a model of myocardial preservation – the rat isolated working heart
Ischemia‐reperfusion injury plays an important role in the development of primary allograft failure after heart transplantation. Inhibition of the Na+/H+ exchanger is one of the most promisingExpand
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A Recombinant Human Neuregulin-1 Peptide Improves Preservation of the Rodent Heart After Prolonged Hypothermic Storage
Background. Donor hearts are subjected to ischemia-reperfusion injury during transplantation. Recombinant human neuregulin (rhNRG)-1 peptide attenuates myocardial injury in various animal models ofExpand
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Improved Poststorage Cardiac Function by Poly (ADP-ribose) Polymerase Inhibition: Role of Phosphatidylinositol 3-Kinase Akt Pathway
Background. Inhibition of poly(ADP-ribose) polymerase 1 (PARP) has been shown to be effective in minimizing cardiac ischemia reperfusion injury. We investigated the cardioprotective effect of theExpand
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Cardio-protective signalling by glyceryl trinitrate and cariporide in a model of donor heart preservation.
BACKGROUND Storage of donor hearts in cardioplegic solutions supplemented with agents that mimic the ischaemic preconditioning response enhanced their post-reperfusion function. The present studyExpand
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A Novel Selenium Compound Enhances Wound Closure and Improves Microvascular Perfusion: Implications for Wound Healing
Selenoproteins (eg glutathione peroxidases, thioredoxin redoxin reductases, some methionine sulfoxide reductases) play a key role in reducing oxidative stress. Diabetes is linked with impaired woundExpand