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Diffuse large B-cell lymphoma outcome prediction by gene-expression profiling and supervised machine learning
Genes implicated in DLBCL outcome included some that regulate responses to B-cell–receptor signaling, critical serine/threonine phosphorylation pathways and apoptosis, and identify rational targets for intervention.
Regulation of the Germinal Center Response by MicroRNA-155
It is shown that the evolutionarily conserved microRNA-155 has an important role in the mammalian immune system, specifically in regulating T helper cell differentiation and the germinal center reaction to produce an optimal T cell–dependent antibody response.
tp53 mutant zebrafish develop malignant peripheral nerve sheath tumors.
- S. Berghmans, Ryan D. Murphey, +10 authors A. Look
- Biology, MedicineProceedings of the National Academy of Sciences…
- 11 January 2005
These mutant zebrafish lines provide a unique platform for modifier screens to identify genetic mutations or small molecules that affect tp53-related pathways, including apoptosis, cell-cycle delay, and tumor suppression.
Integrative analysis reveals selective 9p24.1 amplification, increased PD-1 ligand expression, and further induction via JAK2 in nodular sclerosing Hodgkin lymphoma and primary mediastinal large…
High-resolution copy number data with transcriptional profiles are integrated and identified the immunoregulatory genes, PD-L1 andPD-L2, as key targets at the 9p24.1 amplification peak in HL and MLBCL cell lines, defining the PD-1 pathway and JAK2 as complementary rational therapeutic targets.
The molecular signature of mediastinal large B-cell lymphoma differs from that of other diffuse large B-cell lymphomas and shares features with classical Hodgkin lymphoma.
A molecular link between MLBCL and cHL and a shared survival pathway is identified and a classifier of these diseases is developed.
Molecular profiling of diffuse large B-cell lymphoma identifies robust subtypes including one characterized by host inflammatory response.
Tumor microenvironment and host inflammatory response as defining features in DLBCL are identified and rational treatment targets in specificDLBCL subsets are suggested.
Loss of Runx1 perturbs adult hematopoiesis and is associated with a myeloproliferative phenotype.
It is indicated that Runx1 deficiency has markedly different consequences during development compared with adult hematopoiesis, and insight into the phenotypic manifestations of Runx 1 deficiency in hematoietic malignancies is provided.
H3K79 methylation profiles define murine and human MLL-AF4 leukemias.
It is demonstrated that ectopic H3K79 methylation is a distinguishing feature of murine and human MLL-AF4 ALLs and is important for maintenance of MLL -AF4-driven gene expression.
Mesenchyme Forkhead 1 (FOXC2) plays a key role in metastasis and is associated with aggressive basal-like breast cancers
- Sendurai A Mani, Jing Yang, +7 authors R. Weinberg
- Biology, MedicineProceedings of the National Academy of Sciences
- 12 June 2007
Observations indicate that FOXC2 plays a central role in promoting invasion and metastasis and that it may prove to be a highly specific molecular marker for human basal-like breast cancers.
Spectrum of Epstein-Barr virus-associated diseases.
The current understanding of the role of EBV in the development of Burkitt lymphoma, Hodgkin lymphomas, nasopharyngeal carcinoma, and other EBV-associated diseases is discussed.