J. Kusel

Publications147
h-index31
Citations3,220
Highly Influential Citations59
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Praziquantel: an urgent and exciting challenge.
The anthelmintic drug praziquantel has proved useful in the treatment of schistosomiasis. The precise mechanism by which praziquantel kills the parasites has yet to be elucidated. Here, John Kusel… Expand
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Increased oviposition and growth in immature Biomphalaria glabrata after exposure to Schistosoma mansoni.
Biomphalaria glabrata snails are known to be castrated by infection with the trematode parasite Schistosoma mansoni 4-6 weeks post-infection. The pattern of oviposition in the first 35 days… Expand
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Resistance of Schistosoma mansoni to praziquantel: is there a problem?
Evidence for resistance to praziquantel (PZQ) in Schistosoma mansoni has been sought in parasites taken from treated, but uncured human patients, and in a laboratory isolate of S. mansoni subjected… Expand
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The lateral diffusion of lipid probes in the surface membrane of Schistosoma mansoni
The technique of fluorescence recovery after photobleaching was used to measure the lateral diffusion of fluorescent lipid analogues in the surface membrane of Schistosoma mansoni. Our data reveal… Expand
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Schistosomiasis control: keep taking the tablets.
Despite the limited reports of praziquantel resistance, the relative success of chemotherapy-based control programmes for schistosomiasis has prompted overdue efforts to expand the use of cheap,… Expand
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Schistosoma mansoni: a method for inducing resistance to praziquantel using infected Biomphalaria glabrata snails.
To elucidate the mechanisms of antischistosoma resistance, drug-resistant Schistosoma mansoni laboratory isolates are essential. We developed a new method for inducing resistance to praziquantel… Expand
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Increased exposure of parasite antigens at the surface of adult male Schistosoma mansoni exposed to praziquantel in vitro.
Praziquantel is a broad-spectrum anthelmintic active against schistosome species which are major parasites of man. Two major effects on Schistosoma mansoni have been demonstrated; (i) spastic… Expand
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The schistosome in the mammalian host: understanding the mechanisms of adaptation.
In this review, we envisage the host environment, not as a hostile one, since the schistosome thrives there, but as one in which the relationship between the two organisms consists of constant… Expand
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Studies of chemotactic factor-induced polarity in human neutrophils. Lipid mobility, receptor distribution and the time-sequence of polarization.
Differences in membrane composition between the anterior and posterior poles of human blood neutrophils on exposure to chemoattractant were studied using a laser microscope, and the effects of… Expand
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Schistosoma mansoni: expression of Fes-like tyrosine kinase SmFes in the tegument and terebratorium suggests its involvement in host penetration.
Protein Tyrosine Kinases (PTKs) are important molecules in intra- and inter-cellular communication, playing a major role in signal transduction processes. We have previously identified and… Expand
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