• Publications
  • Influence
Rating neurologic impairment in multiple sclerosis
TLDR
A new Expanded Disability Status Scale (EDSS) is presented, with each of the former steps (1,2,3 … 9) now divided into two (1.0, 1.5, 2.0 … 9).
Epidemiologic evidence for multiple sclerosis as an infection
  • J. Kurtzke
  • Medicine
    Clinical Microbiology Reviews
  • 1 October 1993
TLDR
It is believed that clinical MS is the rare late outcome of a specific, but unknown, infectious disease of adolescence and young adulthood and that this infection could well be caused by a thus-far-unidentified (retro)virus.
PROBLEMS OF EXPERIMENTAL TRIALS OF THERAPY IN MULTIPLE SCLEROSIS: REPORT BY THE PANEL ON THE EVALUATION OF EXPERIMENTAL TRIALS OF THERAPY IN MULTIPLE SCLEROSIS
TLDR
Since its etiology and pathogenesis have eluded detection, it is not surprising that therapeutic attempts have been empiric and often unscientific.
On the evaluation of disability in multiple sclerosis
  • J. Kurtzke
  • Medicine, Psychology
    Neurology
  • 1 August 1961
TLDR
A quantitative evaluation of severity of the disease process two or more points in time could provide, for large groups under simultaneous evaluation, a reliable indication of the results of therapy.
An epidemiological study of neuromyelitis optica in Cuba
TLDR
This Cuban multiethnic population had a prevalence of NMO and an estimated average annual incidence rate of 0.053 per 100,000 with no differences by ethnicity, and the predominant clinical form was relapsing over monophasic.
A New Scale for Evaluating Disability in Multiple Sclerosis
  • J. Kurtzke
  • Medicine, Psychology
    Neurology
  • 1 August 1955
TLDR
The scale to be presented was devised to evaluate a possible therapeutic agent for multiple sclerosis and was used to measure status on admission to and discharge from the hospital in order to establish a baseline with which to compare the in-hospital course of groups of patients.
Warfarin in the prevention of stroke associated with nonrheumatic atrial fibrillation. Veterans Affairs Stroke Prevention in Nonrheumatic Atrial Fibrillation Investigators.
TLDR
Low-intensity anticoagulation with warfarin prevented cerebral infarction in patients with nonrheumatic atrial fibrillation without producing an excess risk of major hemorrhage, and this benefit extended to patients over 70 years of age.
Epidemiology of spinal cord injury
  • J. Kurtzke
  • Medicine
    Experimental Neurology
  • 1 September 1975
Multiple sclerosis in time and space--geographic clues to cause.
  • J. Kurtzke
  • Medicine
    Journal of neurovirology
  • 1 May 2000
TLDR
MS is ordinarily acquired in early adolescence with a lengthy latency before symptom onset, so search for PMSA is best attempted on the Faroes where there are regions still free of MS after 50 years.
Multiple sclerosis in US veterans of the Vietnam era and later military service: Race, sex, and geography
TLDR
Residence by individual state at birth and service entry for white men further supported this decreasing geographic differential, and marked changes in geography, sex, and race in such a short interval strongly imply a primary environmental factor in the cause or precipitation of this disease.
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