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The structural basis of the activation of Ras by Sos
TLDR
The crystal structure of human H-Ras complexed with the Ras guanine-nucleotide-exchange-factor region of the Son of sevenless (Sos) protein has been determined at 2.8 Å resolution and shows a structure that allows nucleotide release and rebinding.
Structural mechanism for STI-571 inhibition of abelson tyrosine kinase.
TLDR
The results suggest that compounds that exploit the distinctive inactivation mechanisms of individual protein kinases can achieve both high affinity and high specificity.
Crystal structure of the Src family tyrosine kinase Hck
TLDR
The crystal structure of the haematopoietic cell kinase Hck has been determined at 2.6/2.9 Å resolution and the conformation of the active site has similarities with that of inactive cyclin-dependent protein kinases.
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