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Flt-1 lacking the tyrosine kinase domain is sufficient for normal development and angiogenesis in mice.
Receptor tyrosine kinases Flt-1 and Flk-1/KDR, and their ligand, the vascular endothelial growth factor (VEGF), were shown to be essential for angiogenesis in the mouse embryo by gene targeting.Expand
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Altered microtubule organization in small-calibre axons of mice lacking tau protein
THE tau gene encodes a protein (Tau) that is a major neuronal microtubule-associated protein localized mostly in axons1–4. It has microtubule-binding and tubulin-polymerizing activity in vitro 3,4Expand
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Ataxia and epileptic seizures in mice lacking type 1 inositol 1,4,5-trisphosphate receptor
THE inositol 1,4,5-trisphosphate (InsP3) receptor acts as an InsP3-gated Ca2+ release channel in a variety of cell types1,2. Type 1 InsP3 receptor (IP3R1) is the major neuronal member of the IP3RExpand
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Renal carcinogenesis, hepatic hemangiomatosis, and embryonic lethality caused by a germ-line Tsc2 mutation in mice.
Germ-line mutations of the human TSC2 tumor suppressor gene cause tuberous sclerosis (TSC), a disease characterized by the development of hamartomas in various organs. In the Eker rat, however, aExpand
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Negative Regulation of BMP/Smad Signaling by Tob in Osteoblasts
Bone morphogenetic protein (BMP) controls osteoblast proliferation and differentiation through Smad proteins. Here we show that Tob, a member of the emerging family of antiproliferative proteins, isExpand
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Placental defect and embryonic lethality in mice lacking hepatocyte growth factor/scatter factor
HEPATOCYTE growth factor/scatter factor (HGF/SF) functions as a mitogen, motogen and morphogen for a variety of cultured cells1–7. The genes for HGF/SF and its receptor (the c-met protooncogeneExpand
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G protein-coupled cholecystokinin-B/gastrin receptors are responsible for physiological cell growth of the stomach mucosa in vivo.
  • A. Nagata, M. Ito, +6 authors T. Noda
  • Biology, Medicine
  • Proceedings of the National Academy of Sciences…
  • 15 October 1996
Many peptide hormone and neurotransmitter receptors belonging to the seven membrane-spanning G protein-coupled receptor family have been shown to transmit ligand-dependent mitogenic signals in vitro.Expand
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Universal GFP reporter for the study of vascular development
Summary: We report the generation and characterization of transgenic mouse and zebrafish expressing green fluorescent protein (GFP) specifically in vascular endothelial cells in a relatively uniformExpand
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Mouse Zic1 Is Involved in Cerebellar Development
Zic genes encode zinc finger proteins, the expression of which is highly restricted to cerebellar granule cells and their precursors. These genes are homologs of theDrosophila pair-rule geneExpand
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Unrestrained nociceptive response and disregulation of hearing ability in mice lacking the nociceptin/orphaninFQ receptor
In the G‐protein‐coupled receptor superfamily, the opioid receptor subfamily is constituted of the three distinct opioid receptors (namely δ‐, μ‐ and κ‐subtypes) and the receptor for nociceptin (alsoExpand
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