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The stabilization of hypoxia inducible factor modulates differentiation status and inhibits the proliferation of mouse embryonic stem cells.
TLDR
The short term stabilization of HIF mediated by the PHD inhibitors JNJ and DMOG and hypoxia did not prevent the spontaneous loss of pluripotency markers in mESC, however, it significantly downregulated the proliferation of these cells. Expand
Melatonin promotes cardiomyogenesis of embryonic stem cells via inhibition of HIF‐1α stabilization
TLDR
Melatonin significantly upregulated the expression of cardiac cell‐specific markers as well as the percentage of myosin heavy chain‐positive cells and increased Sirt‐1 levels in a HIF‐1α‐dependent manner, uncovering new mechanisms underlying the maturation of cardiac progenitor cells. Expand
Simple non-invasive analysis of embryonic stem cell-derived cardiomyocytes beating in vitro.
TLDR
CB Analyser is a useful tool for evaluating the functions of both developing and mature cardiomyocytes under various conditions in vitro, and during differentiation, the beat peak width decreased, which corresponded to the increased speed of an individual pulse. Expand
Opioid receptors and opioid peptides in the cardiomyogenesis of mouse embryonic stem cells
TLDR
The overall data do not support the notion that opioid peptides have a significant potential to promote the spontaneous cardiomyogenesis of mES cells in vitro. Expand
HIF-1alpha Deficiency Attenuates the Cardiomyogenesis of Mouse Embryonic Stem Cells
TLDR
It is demonstrated that HIF-1α deficiency significantly altered the quality and quantity of mESC-derived cardiomyocytes and was accompanied with lower mRNA and protein levels of cardiac cell specific markers and with a decreasing percentage of myosin heavy chain α and β, and cardiac troponin T-positive cells. Expand
The acceleration of cardiomyogenesis in embryonic stem cells in vitro by serum depletion does not increase the number of developed cardiomyocytes
TLDR
Modifications of the basic protocol for ES cell differentiation into cardiomyocytes were evaluated in order to increase the yield and differentiation status of developed cardiomers, and serum depletion was identified as a key factor that intensifiedCardiomyogenesis under serum depleted conditions. Expand
Neural Differentiation Is Inhibited through HIF1α/β-Catenin Signaling in Embryoid Bodies
TLDR
The results emphasize the regulatory role of HIF1α in β-catenin stabilization during spontaneous differentiation, which seems to be a crucial mechanism for the natural inhibition of premature neural differentiation. Expand
Hypoxia favors myosin heavy chain beta gene expression in an Hif-1alpha-dependent manner.
TLDR
In in vitro models of mouse embryonic stem cell-derived cardiomyocytes, it was shown that hypoxia or the pharmacological stabilization of HIFs significantly increased MHCbeta (Myh7) gene expression, and the recognized and important role of Hif in the regulation of heart regenerative processes could be highly significant for the development of novel therapeutic interventions in heart failure. Expand
Nitro-oleic acid regulates differentiation of embryonic stem cells
Nitro-fatty acids (NO2-FA) are pluripotent signaling molecules endogenously generated as an adaptive response of organism to oxidative and nitrative stress. Recently, we have discovered some newExpand
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