• Publications
  • Influence
Antidepressant effects of ketamine in depressed patients
A first placebo-controlled, double-blinded trial to assess the treatment effects of a single dose of an N-methyl-D-aspartate (NMDA) receptor antagonist in patients with depression suggests a potential role for NMDA receptor-modulating drugs in the treatment of depression.
Subanesthetic effects of the noncompetitive NMDA antagonist, ketamine, in humans. Psychotomimetic, perceptual, cognitive, and neuroendocrine responses.
These data indicate that N-methyl-D-aspartate antagonists produce a broad range of symptoms, behaviors, and cognitive deficits that resemble aspects of endogenous psychoses, particularly schizophrenia and dissociative states.
Measurement of Dissociative States with the Clinician-Administered Dissociative States Scale (CADSS)
Initial analyses indicated good interrater reliability and construct validity and sensitivity of the CADSS to discriminate patients with dissociative disorders from patients with other psychiatric disorders and healthy subjects.
Targeting the glutamatergic system to develop novel, improved therapeutics for mood disorders
There is growing evidence that the glutamatergic system is central to the neurobiology and treatment of mood disorders and exciting new prospects for the development of improved therapeutics for these devastating disorders are discussed.
Move over ANOVA: progress in analyzing repeated-measures data and its reflection in papers published in the Archives of General Psychiatry.
Mixed-effects models use all available data, can properly account for correlation between repeated measurements on the same subject, have greater flexibility to model time effects, and can handle missing data more appropriately makes them the preferred choice for the analysis of repeated-measures data.
The Psychotomimetic Effects of Intravenous Delta-9-Tetrahydrocannabinol in Healthy Individuals: Implications for Psychosis
It is indicated that Δ-9-THC produces a broad range of transient symptoms, behaviors, and cognitive deficits in healthy individuals that resemble some aspects of endogenous psychoses and warrant further study of whether brain cannabinoid receptor function contributes to the pathophysiology of psychotic disorders.
Social supports and serotonin transporter gene moderate depression in maltreated children.
Risk for negative outcomes may be modified by both genetic and environmental factors, with the quality and availability of social supports among the most important environmental factors in promoting resiliency in maltreated children, even in the presence of a genotype expected to confer vulnerability for psychiatric disorder.
Brain-Derived Neurotrophic Factor–5-HTTLPR Gene Interactions and Environmental Modifiers of Depression in Children
This is the first investigation to demonstrate a gene-by-gene interaction conveying vulnerability to depression, and the current data show a protective effect of social supports in ameliorating genetic and environmental risk for psychopathology.
Trauma and the Vietnam War Generation
  • J. Krystal
  • History
    The Yale Journal of Biology and Medicine
  • 1992
presentations, treatment, prognosis, and non-clinical aspects such as medico-legal, ethical, and counseling aspects of the disease. Occasionally, the British perspective makes it slightly less
Elevated CSF corticotropin-releasing factor concentrations in posttraumatic stress disorder.
Higher CSFCRF concentrations in patients with PTSD may reflect alterations in stress-related neurotransmitter systems, and the higher CSF CRF concentrations may play a role in disturbances of arousal in Patients with PTSD.