J. Krystal
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- Publications
- Influence
Antidepressant effects of ketamine in depressed patients
- R. Berman, A. Cappiello, A. Anand, D. Oren, J. Krystal
- Psychology, Medicine
- Biological Psychiatry
- 15 February 2000
BACKGROUND
A growing body of preclinical research suggests that brain glutamate systems may be involved in the pathophysiology of major depression and the mechanism of action of antidepressants. This… Expand
Subanesthetic effects of the noncompetitive NMDA antagonist, ketamine, in humans. Psychotomimetic, perceptual, cognitive, and neuroendocrine responses.
- J. Krystal, L. Karper, +6 authors D. Charney
- Psychology, Medicine
- Archives of general psychiatry
- 1 March 1994
BACKGROUND
To characterize further behavioral, cognitive, neuroendocrine, and physiological effects of subanesthetic doses of ketamine hydrochloride in healthy human subjects. Ketamine, a… Expand
Measurement of Dissociative States with the Clinician-Administered Dissociative States Scale (CADSS)
- J. Bremner, J. Krystal, +4 authors C. Mazure
- Medicine, Psychology
- Journal of traumatic stress
- 1998
The purpose of this study was to develop an instrument for the measurement of present-state dissociative symptoms, the Clinician Administered Dissociative States Scale (CADSS). Reported here are… Expand
Targeting the glutamatergic system to develop novel, improved therapeutics for mood disorders
- G. Sanacora, C. Zárate, J. Krystal, H. Manji
- Medicine
- Nature Reviews Drug Discovery
- 1 May 2008
Mood disorders are common, chronic, recurrent mental illnesses that affect the lives of millions of individuals worldwide. To date, the monoaminergic systems (serotonergic, noradrenergic and… Expand
Move over ANOVA: progress in analyzing repeated-measures data and its reflection in papers published in the Archives of General Psychiatry.
- R. Gueorguieva, J. Krystal
- Medicine, Psychology
- Archives of general psychiatry
- 1 March 2004
BACKGROUND
The analysis of repeated-measures data presents challenges to investigators and is a topic for ongoing discussion in the Archives of General Psychiatry. Traditional methods of statistical… Expand
The Psychotomimetic Effects of Intravenous Delta-9-Tetrahydrocannabinol in Healthy Individuals: Implications for Psychosis
- D. D’Souza, E. Perry, +6 authors J. Krystal
- Medicine, Psychology
- Neuropsychopharmacology
- 2 June 2004
Recent advances in the understanding of brain cannabinoid receptor function have renewed interest in the association between cannabinoid compounds and psychosis. In a 3-day, double-blind, randomized,… Expand
The role of default network deactivation in cognition and disease
- A. Anticevic, Michael W. Cole, J. Murray, P. Corlett, J. Krystal
- Medicine, Psychology
- Trends in Cognitive Sciences
- 1 December 2012
A considerable body of evidence has accumulated over recent years on the functions of the default-mode network (DMN)--a set of brain regions whose activity is high when the mind is not engaged in… Expand
Subtype-specific alterations of gamma-aminobutyric acid and glutamate in patients with major depression.
- G. Sanacora, R. Gueorguieva, +5 authors G. Mason
- Medicine, Psychology
- Archives of general psychiatry
- 1 July 2004
BACKGROUND
Measurement of cortical gamma-aminobutyric acid (GABA) and glutamate concentrations is possible using proton magnetic resonance spectroscopy. An initial report, using this technique,… Expand
Elevated CSF corticotropin-releasing factor concentrations in posttraumatic stress disorder.
- J. Bremner, J. Licinio, +5 authors D. Charney
- Psychology, Medicine
- The American journal of psychiatry
- 1 May 1997
OBJECTIVE
Corticotropin-releasing factor (CRF) and somatostatin both play important roles in mediating responses to acute and chronic stress. The purpose of this study was to measure CSF… Expand