Antidepressant effects of ketamine in depressed patients
Subanesthetic effects of the noncompetitive NMDA antagonist, ketamine, in humans. Psychotomimetic, perceptual, cognitive, and neuroendocrine responses.
These data indicate that N-methyl-D-aspartate antagonists produce a broad range of symptoms, behaviors, and cognitive deficits that resemble aspects of endogenous psychoses, particularly schizophrenia and dissociative states.
Measurement of Dissociative States with the Clinician-Administered Dissociative States Scale (CADSS)
Initial analyses indicated good interrater reliability and construct validity and sensitivity of the CADSS to discriminate patients with dissociative disorders from patients with other psychiatric disorders and healthy subjects.
Targeting the glutamatergic system to develop novel, improved therapeutics for mood disorders
- G. Sanacora, C. Zarate, J. Krystal, H. Manji
- Psychology, BiologyNature reviews. Drug discovery
- 1 May 2008
There is growing evidence that the glutamatergic system is central to the neurobiology and treatment of mood disorders and exciting new prospects for the development of improved therapeutics for these devastating disorders are discussed.
Move over ANOVA: progress in analyzing repeated-measures data and its reflection in papers published in the Archives of General Psychiatry.
Mixed-effects models use all available data, can properly account for correlation between repeated measurements on the same subject, have greater flexibility to model time effects, and can handle missing data more appropriately makes them the preferred choice for the analysis of repeated-measures data.
The Psychotomimetic Effects of Intravenous Delta-9-Tetrahydrocannabinol in Healthy Individuals: Implications for Psychosis
It is indicated that Δ-9-THC produces a broad range of transient symptoms, behaviors, and cognitive deficits in healthy individuals that resemble some aspects of endogenous psychoses and warrant further study of whether brain cannabinoid receptor function contributes to the pathophysiology of psychotic disorders.
Synaptic plasticity and depression: new insights from stress and rapid-acting antidepressants
- R. Duman, G. Aghajanian, G. Sanacora, J. Krystal
- Psychology, BiologyNature Network Boston
- 1 March 2016
Treatment with new agents results in an improvement in mood ratings within hours of dosing patients who are resistant to typical antidepressants, and these new agents have also been shown to reverse the synaptic deficits caused by stress.
The role of default network deactivation in cognition and disease
Transcranial magnetic stimulation of left temporoparietal cortex and medication-resistant auditory hallucinations.
Auditory hallucinations were robustly improved with rTMS relative to sham stimulation, and the mechanism of AHs involves activation of the left temporoparietal cortex, which suggests that one-hertz rT MS deserves additional study as a possible treatment for this syndrome.
Trauma and the Vietnam War Generation
- J. Krystal
- MedicineThe Yale Journal of Biology and Medicine
The book is a useful review of the subject areas mentioned, for medical students, house officers, or practicing physicians, and occasionally, molecular terms are not explained, which would force readers who have not been trained recently to do some background research.