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Perioperative Oral Pregabalin Reduces Chronic Pain After Total Knee Arthroplasty: A Prospective, Randomized, Controlled Trial
TLDR
Perioperative pregabalin administration reduces the incidence of chronic neuropathic pain after TKA, with less opioid consumption and better range of motion during the first 30 days of rehabilitation, however, in the doses tested, it is associated with a higher risk of early postoperative sedation and confusion. Expand
A current review of molecular mechanisms regarding osteoarthritis and pain.
TLDR
Several biochemical mediators involved in OA and pain are explored, and a framework for the understanding of potential biologic therapies in the treatment of degenerative joint disease in the future is provided. Expand
Intrathecal Magnesium Prolongs Fentanyl Analgesia: A Prospective, Randomized, Controlled Trial
TLDR
Intrathecal magnesium prolongs spinal opioid analgesia in humans and suggest that the availability of an intrathecal N-methyl-d-aspartate receptor antagonist could be of clinical importance for pain management. Expand
Effects of perioperative administration of a selective cyclooxygenase 2 inhibitor on pain management and recovery of function after knee replacement: a randomized controlled trial.
TLDR
Perioperative use of an inhibitor of cyclooxygenase 2 is an effective component of multimodal analgesia that reduces opioid consumption, pain, vomiting, and sleep disturbance, with improved knee range of motion after TKA. Expand
Distribution and retrograde transport of trophic factors in the central nervous system: functional implications for the treatment of neurodegenerative diseases
TLDR
Since select neurotrophins traffic anterogradely and retrogradely within the nervous system, these proteins could be used to treat neurological diseases such as Alzheimer's disease, Parkinson's disease and amyotrophic lateral sclerosis. Expand
Upregulation of Prostaglandin E2 and Interleukins in the Central Nervous System and Peripheral Tissue during and after Surgery in Humans
TLDR
The results suggest that upregulation of prostaglandin E2 and interleukin 6 at central sites is an important component of surgery induced inflammatory response in patients and may influence clinical outcome. Expand
MicroRNA-146a is linked to pain-related pathophysiology of osteoarthritis.
TLDR
The findings suggest that miR-146a controls knee joint homeostasis and OA-associated algesia by balancing inflammatory responses in cartilage and synovium with pain-related factors in glial cells, and may be useful for the treatment of both cartilage regeneration and pain symptoms caused by OA. Expand
Alteration of sensory neurons and spinal response to an experimental osteoarthritis pain model.
TLDR
The results indicate that MIA-induced joint degeneration in rats generates an animal model that is suitable for mechanistic and pharmacologic studies on nociceptive pain pathways caused by OA, and provide key in vivo evidence that OA pain is caused by central sensitization through communication between peripheral OA nocICEptors and the central sensory system. Expand
Intrathecal Baclofen for Severe Spinal Spasticity
Intrathecal Baclofen for Severe Spinal Spasticity
TLDR
It is suggested that intrathecal baclofen is an effective long-term treatment for spinal spasticity that has not responded to oral bacl ofen. Expand
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