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Mixed mechanisms of multi-site phosphorylation
Multi-site phosphorylation is ubiquitous in cell biology and has been widely studied experimentally and theoretically. The underlying chemical modification mechanisms are typically assumed to beExpand
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Autoregulatory systems controlling translation factor expression: thermostat-like control of translational accuracy.
In both prokaryotes and eukaryotes, the expression of a large number of genes is controlled by negative feedback, in some cases operating at the level of translation of the mRNA transcript. OfExpand
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Biphasic responses in multi-site phosphorylation systems
Multi-site phosphorylation systems are repeatedly encountered in cellular biology and multi-site modification is a basic building block of post-translational modification. In this paper, weExpand
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A mathematical modelling framework for elucidating the role of feedback control in translation termination.
Translation is the final stage of gene expression where messenger RNA is used as a template for protein polymerization from appropriate amino acids. Release of the completed protein requires aExpand
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Model-Based Analysis of Cell Cycle Responses to Dynamically Changing Environments
Cell cycle progression is carefully coordinated with a cell’s intra- and extracellular environment. While some pathways have been identified that communicate information from the environment to theExpand
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Use of mathematical models to understand anticancer drug delivery and its effect on solid tumors.
The transport of anticancer drugs and their effect on tumor cells involve a number of physical and biochemical processes. Mathematical modeling provides a tool to help us understand the interactionExpand
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Regulation of release factor expression using a translational negative feedback loop: a systems analysis.
The essential eukaryote release factor eRF1, encoded by the yeast SUP45 gene, recognizes stop codons during ribosomal translation. SUP45 nonsense alleles are, however, viable due to the establishmentExpand
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Receptor-mediated and intrinsic polarization and their interaction in chemotaxing cells.
Polarization--the clear and persistent localization of different signaling molecules to opposite ends of the cell-is critical for effective chemotaxis in eukaryotic systems. In many systems,Expand
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A systems-based mathematical modelling framework for investigating the effect of drugs on solid tumours
BackgroundElucidating the effects of drugs on solid tumours is a highly challenging multi-level problem, since this involves many complexities associated with transport and cellular response, whichExpand
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Effects of saturation and enzyme limitation in feedforward adaptive signal transduction.
  • J. Krishnan
  • Medicine, Biology
  • IET systems biology
  • 1 May 2011
In this study, the author examines the effects of saturation and enzyme limitation in temporal and spatial signal transduction in a generic feedforward adaptive module. The feedforward moduleExpand
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