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Induction of B7-1 in podocytes is associated with nephrotic syndrome.
TLDR
Upregulation of B7-1 in podocytes may contribute to the pathogenesis of proteinuria by disrupting the glomerular filter and provides a novel molecular target to tackle proteinuric kidney diseases.
YAC complementation shows a requirement for Wt1 in the development of epicardium, adrenal gland and throughout nephrogenesis.
TLDR
Analysis of the observed hypoplastic kidneys demonstrate a continuous requirement for WT1 during nephrogenesis, in particular, in the formation of mature glomeruli, and suggest a general requirement for this protein in theformation of organs derived from the intermediate mesoderm.
The LIM homeobox gene Lhx9 is essential for mouse gonad formation
TLDR
It is shown that transcripts of the LIM homeobox gene Lhx9 are present in urogenital ridges of mice at embryonic day 9.5; later they localize to the interstitial region as morphological differentiation occurs, indicating that LHX9 mutations may underlie certain forms of isolated gonadal agenesis in humans.
Alpha 3 beta 1 integrin has a crucial role in kidney and lung organogenesis.
TLDR
A role for integrin receptors in basement membrane organization and branching morphogenesis is indicated, and mutant mice with a mutation targeted to the murine alpha3 integrin gene show abnormal kidney and lung development.
Palmitoylation of tetraspanin proteins: modulation of CD151 lateral interactions, subcellular distribution, and integrin-dependent cell morphology.
TLDR
It is demonstrated that multiple tetraspanin (transmembrane 4 superfamily) proteins are palmitoylated, in either the Golgi or a post-Golgi compartment, and expression of the tetra-CD151 mutant profoundly altered alpha 3 integrin-deficient kidney epithelial cells, such that they converted from a dispersed, elongated morphology to an epithelium-like cobblestone clustering.
Reelin binds alpha3beta1 integrin and inhibits neuronal migration.
TLDR
Reelin inhibits migration of cortical neurons and enables detachment of neurons from radial glia and may arrest neuronal migration and promote normal cortical lamination by binding alpha3beta1 integrin and modulating integrin-mediated cellular adhesion.
Epithelial cell alpha3beta1 integrin links beta-catenin and Smad signaling to promote myofibroblast formation and pulmonary fibrosis.
TLDR
Findings demonstrate epithelial integrin-dependent profibrotic crosstalk between beta-catenin and Smad signaling and support the hypothesis that EMT is an important contributor to pathologic fibrosis.
α3β1 Integrin Is Required for Normal Development of the Epidermal Basement Membrane
TLDR
A novel role for α3β1 in establishment and/or maintenance of basement membrane integrity, while α6β4 is required for stable adhesion of the epidermis to the basement membrane through hemidesmosomes is supported.
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