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- Publications
- Influence
WT-1 is required for early kidney development
- J. Kreidberg, H. Sariola, J. Loring, M. Maeda, R. Jaenisch
- Biology, Medicine
- Cell
- 27 August 1993
In humans, germline mutations of the WT-1 tumor suppressor gene are associated with both Wilms' tumors and urogenital malformations. To develop a model system for the molecular analysis of urogenital… Expand
Induction of B7-1 in podocytes is associated with nephrotic syndrome.
- J. Reiser, G. von Gersdorff, +15 authors P. Mundel
- Biology, Medicine
- The Journal of clinical investigation
- 15 May 2004
Kidney podocytes and their slit diaphragms form the final barrier to urinary protein loss. This explains why podocyte injury is typically associated with nephrotic syndrome. The present study… Expand
YAC complementation shows a requirement for Wt1 in the development of epicardium, adrenal gland and throughout nephrogenesis.
- A. Moore, L. McInnes, J. Kreidberg, N. Hastie, A. Schedl
- Biology, Medicine
- Development
- 1 May 1999
The Wilms' Tumour gene WT1 has important functions during development. Knock-out mice were shown to have defects in the urogenital system and to die at embryonic day E13.5, probably due to heart… Expand
The LIM homeobox gene Lhx9 is essential for mouse gonad formation
- O. Birk, D. Casiano, +9 authors H. Westphal
- Biology, Medicine
- Nature
- 24 February 2000
During mammalian embryonic development, the ovaries and testes develop from somatic cells of the urogenital ridges as indifferent gonads, harbouring primordial germ cells that have migrated there.… Expand
Alpha 3 beta 1 integrin has a crucial role in kidney and lung organogenesis.
- J. Kreidberg, M. J. Donovan, +4 authors R. Jaenisch
- Biology, Medicine
- Development
- 1 November 1996
A mutation was targeted to the murine alpha3 integrin gene. Homozygous mutant mice survived to birth, but died during the neonatal period. The mutation caused abnormal kidney and lung development.… Expand
Palmitoylation of tetraspanin proteins: modulation of CD151 lateral interactions, subcellular distribution, and integrin-dependent cell morphology.
Here we demonstrate that multiple tetraspanin (transmembrane 4 superfamily) proteins are palmitoylated, in either the Golgi or a post-Golgi compartment. Using CD151 as a model tetraspanin, we… Expand
Epithelial cell alpha3beta1 integrin links beta-catenin and Smad signaling to promote myofibroblast formation and pulmonary fibrosis.
- K. Kim, Y. Wei, +8 authors H. Chapman
- Biology, Medicine
- The Journal of clinical investigation
- 22 December 2008
Pulmonary fibrosis, in particular idiopathic pulmonary fibrosis (IPF), results from aberrant wound healing and scarification. One population of fibroblasts involved in the fibrotic process is thought… Expand
Reelin binds alpha3beta1 integrin and inhibits neuronal migration.
- L. Dulabon, E. Olson, +5 authors E. Anton
- Medicine
- Neuron
- 2000
Mice that are mutant for Reelin or Dab1, or doubly mutant for the VLDL receptor (VLDLR) and ApoE receptor 2 (ApoER2), show disorders of cerebral cortical lamination. How Reelin and its receptors… Expand
α3β1 Integrin Is Required for Normal Development of the Epidermal Basement Membrane
- C. DiPersio, K. Hodivala-Dilke, R. Jaenisch, J. Kreidberg, R. Hynes
- Biology, Medicine
- The Journal of cell biology
- 5 May 1997
Integrins α3β1 and α6β4 are abundant receptors on keratinocytes for laminin-5, a major component of the basement membrane between the epidermis and the dermis in skin. These integrins are recruited… Expand
Reelin Binds α3β1 Integrin and Inhibits Neuronal Migration
- L. Dulabon, E. Olson, +5 authors E. Anton
- Chemistry
- Neuron
- 1 July 2000
Mice that are mutant for Reelin or Dab1, or doubly mutant for the VLDL receptor (VLDLR) and ApoE receptor 2 (ApoER2), show disorders of cerebral cortical lamination. How Reelin and its receptors… Expand