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Listeria Pathogenesis and Molecular Virulence Determinants
The molecular determinants of Listeria virulence and their mechanism of action are described and the current knowledge on the pathophysiology of listeriosis and the cell biology and host cell responses to Listersia infection is summarized. Expand
Comparative Genomics of Listeria Species
A large number of predicted genes encoding surface and secreted proteins, transporters, and transcriptional regulators are found, consistent with the ability of both species to adapt to diverse environments. Expand
Pathogenicity islands and virulence evolution in Listeria.
This review summarizes current knowledge about the structure, distribution and role in pathogenesis of Listeria virulence loci and Hypotheses about the mode of acquisition and evolution of these loci in this group of Gram-positive bacteria are presented. Expand
Blue and Red Light Modulates SigB-Dependent Gene Transcription, Swimming Motility and Invasiveness in Listeria monocytogenes
The data established that visible, in particular blue light is an important environmental signal with an impact on gene expression and physiology of the non-phototrophic bacterium L. monocytogenes. Expand
Regulation of virulence genes in Listeria.
The analysis of virulence gene expression in vivo, i.e. in infected host cells, indicates that yet uncharacterized bacterial factors other than PrfA, and possibly also host factors, modulate the expression of thePrfA regulon. Expand
The bvr Locus of Listeria monocytogenes Mediates Virulence Gene Repression by β-Glucosides
The regulation of L. monocytogenes virulence genes by sugars appears to be mediated by two separate mechanisms, one presumably involving a CR pathway and another specifically responding to beta-glucosides. Expand
Whole-Genome Sequence of Listeria welshimeri Reveals Common Steps in Genome Reduction with Listeria innocua as Compared to Listeria monocytogenes
The species L. welshimeri appears to have been derived from early evolutionary events and an ancestor more compact than L. monocytogenes that led to the emergence of nonpathogenic Listeria spp, suggesting similar genome evolutionary paths from an ancestor. Expand
A Bacillus cereus cytolytic determinant, cereolysin AB, which comprises the phospholipase C and sphingomyelinase genes: nucleotide sequence and genetic linkage
A cloned cytolytic determinant from the genome of Bacillus cereus GP-4 has been characterized at the molecular level and the presence of two open reading frames was found to be necessary for expression of the hemolytic phenotype by Bacillus subtilis and Escherichia coli hosts. Expand
Pathogenomics of Listeria spp.
This review provides an overview of recent progress in the exploration of genomic, transcriptomic, and proteomic data in Listeria spp. to understand genome evolution and diversity, as well asExpand
Evolutionary history of the genus Listeria and its virulence genes.
Since no traces of lateral gene transfer events could be detected the most parsimonious scenario is that the virulence gene cluster was present in the common ancestor of L. welshimeri and that the pathogenic capability has been lost in two separate events represented by L. innocua and L. seeligeri. Expand