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Adipose tissue quantification by imaging methods: a proposed classification.
An updated classification of total body and regional adipose tissue is proposed, providing a well-defined basis for correlating imaging studies of specific adipose tissues depots with molecular processes and revealing inconsistencies in the use of specific definitions.
Surgical treatment of obesity
Results of bariatric surgery in large case-series followed for at least 10 years consistently demonstrate amelioration of components of the insulin-resistance metabolic syndrome and other comorbidities, significantly improving quality of life.
A Review of the Microcirculation of Adipose Tissue: Anatomic, Metabolic, and Angiogenic Perspectives
An in‐depth analysis of the development of adipose tissue microvasculature indicates that angiogenesis often precedes adipogenesis, and the recent discovery of sites of nuclear regulation of adipocyte differentiation is an indication of the progress that is being made in the further understanding of molecular and cellular events that affect adipOSE tissue growth and, ultimately, adipose tissues microcirculation.
Gene variants and binge eating as predictors of comorbidity and outcome of treatment in severe obesity
Mechanisms and Disease Associations of Haplotype-Dependent Allele-Specific DNA Methylation.
Effects of surgical treatment of the metabolic syndrome on liver fibrosis and cirrhosis.
Binge eating as a major phenotype of melanocortin 4 receptor gene mutations.
- R. Branson, N. Potoczna, J. Kral, K. Lentes, M. Hoehe, F. Horber
- Biology, MedicineThe New England journal of medicine
- 20 March 2003
Binge eating is a major phenotypic characteristic of subjects with a mutation in MC4R, a candidate gene for the control of eating behavior, and no mutations were found in the region of POMC encoding alpha melanocyte-stimulating hormone.
Outcome of Pregnancies after Biliopancreatic Diversion
The results speak in favor of delaying pregnancy in obese women until after the substantial surgical weight loss has occurred, including normalization of gestational weight changes, reduction of fetal macrosomia, andnormalization of the infant's birth-weight.
Relative expansion of extracellular fluid in obese vs. nonobese women.
- M. Waki, J. Kral, M. Mazariegos, J. Wang, R. Pierson, S. Heymsfield
- Biology, MedicineThe American journal of physiology
- 1 August 1991
Fluid volumes are increased in obese women, and the expansion is relatively greater for the extracellular compartment, which may also account in part for the fluid-overload states that often accompany severe obesity.
Large maternal weight loss from obesity surgery prevents transmission of obesity to children who were followed for 2 to 18 years.
The results demonstrate the importance of potentially modifiable epigenetic factors in the cause of obesity and the prevalence of overweight and obesity in children of mothers with large voluntary postsurgical weight loss was similar to that in the general population, with no increase in underweight.