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Adipose tissue quantification by imaging methods: a proposed classification.
Recent advances in imaging techniques and understanding of differences in the molecular biology of adipose tissue has rendered classical anatomy obsolete, requiring a new classification of theExpand
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Surgical treatment of obesity
Obesity is very prevalent. Most treatments fail owing to hard-wired survival mechanisms, linking stress and appetite, which have become grossly maladaptive in the industrial era. AntiobesityExpand
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Gene variants and binge eating as predictors of comorbidity and outcome of treatment in severe obesity
Melanocortin-4 receptor gene (MC4R) variants are associated with obesity and binge eating disorder (BED), whereas the more prevalent proopiomelanocortin (POMC) and leptin receptor gene (LEPR)Expand
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Outcome of Pregnancies after Biliopancreatic Diversion
Background: Severe obesity has deleterious effects on fertility and pregnancy outcomes. Although surgery is the best long-term treatment for severe obesity, there is a risk of gestationalExpand
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Binge eating as a major phenotype of melanocortin 4 receptor gene mutations.
BACKGROUND Obesity, a multifactorial disease caused by the interaction of genetic factors with the environment, is largely polygenic. A few mutations in these genes, such as in the leptin receptorExpand
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Effects of surgical treatment of the metabolic syndrome on liver fibrosis and cirrhosis.
BACKGROUND Both weight loss and gastrointestinal surgery for obesity can cause liver disease, making their role in the treatment of obesity-related liver disease controversial. METHODS Six hundredExpand
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Mechanisms and Disease Associations of Haplotype-Dependent Allele-Specific DNA Methylation.
Haplotype-dependent allele-specific methylation (hap-ASM) can impact disease susceptibility, but maps of this phenomenon using stringent criteria in disease-relevant tissues remain sparse. Here weExpand
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Large maternal weight loss from obesity surgery prevents transmission of obesity to children who were followed for 2 to 18 years.
OBJECTIVE Our aim was to compare the prevalence of obesity in 172 children who were aged 2 to 18 years and born to 113 obese mothers (BMI: 31 +/- 9 kg/m2) with substantial weight loss afterExpand
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Eating fast leads to insulin resistance: findings in middle-aged Japanese men and women.
OBJECTIVE To examine relationships between speed of eating and insulin resistance. METHODS Cross-sectional study of 2704 male (mean age and BMI: 48.2 y and 23.3 kg/m(2)) and 761 female (46.3 y andExpand
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Differential methylation in glucoregulatory genes of offspring born before vs. after maternal gastrointestinal bypass surgery
Obesity and overnutrition during pregnancy affect fetal programming of adult disease. Children born after maternal bariatric gastrointestinal bypass surgery (AMS) are less obese and exhibit improvedExpand
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