Share This Author
Stereotyped position of local synaptic targets in neocortex.
To examine the precision and degree of determinism in the neocortical microcircuitry, optical probing is used to reconstruct microcircuits in layer 5 from mouse primary visual cortex to reveal precisely organized cortical micro Circuits.
An Ultrascalable Solution to Large-scale Neural Tissue Simulation
A novel tissue volume decomposition, and a hybrid branched cable equation solver are developed, which divides the simulation into regular tissue blocks and distributes them on a parallel multithreaded machine.
Unsupervised Segmentation With Dynamical Units
- A. R. Rao, G. Cecchi, Charles C. Peck, J. Kozloski
- Computer ScienceIEEE Transactions on Neural Networks
A novel network to separate mixtures of inputs that have been previously learned is presented and it is argued that this objective function can provide a possible formal interpretation of the binding problem and that the implementation of the network architecture and dynamics is biologically plausible.
A Theory of Loop Formation and Elimination by Spike Timing-Dependent Plasticity
It is shown that the local spike timing-dependent plasticity rule has the effect of regulating the trans-synaptic weights of loops of any length within a simulated network of neurons, and predicted that STDP could also regulate long range functional loops among individual neurons across all brain scales.
Functional neuroanatomy of auditory pathways in the sound‐producing fish Pollimyrus
We have described the acoustic pathway from the ear to the diencephalon in a sound‐producing fish (Pollimyrus) based on simultaneous neurophysiological recordings from single neurons and injections…
Optical probing of neuronal circuits with calcium indicators.
- Z. Peterlin, J. Kozloski, B. Mao, A. Tsiola, R. Yuste
- BiologyProceedings of the National Academy of Sciences…
- 28 March 2000
It is demonstrated that neurons that display somatic calcium transients time-locked to the spikes of a trigger neuron can be monosynaptically connected to it.
Transformations of an Auditory Temporal Code in the Medulla of a Sound-Producing Fish
This paper discovered a class of neurons in which evoked spiking patterns were relatively independent of the stimulus fine structure and appeared to reflect intrinsic properties of the neurons, suggesting that this medullary transformation, from phase-locked afferent input to chopper-like physiology, is basic to vertebrate auditory processing, even within lineages that have not evolved a cochlea.
Predicting cognitive states from wearable recordings of autonomic function
- Elizabeth Webster, N. Sukaviriya, Hung-Yang Chang, J. Kozloski
- Computer ScienceIBM J. Res. Dev.
- 1 March 2017
The proof-of-concept results reported here establish the feasibility of a system that applies the personalized method, which integrates real-time data from any wearable sensor with cognitive/behavioral labels submitted privately by a user, to anticipate cognitive changes, and which then issues alerts.
Automated Reconstruction of Neural Tissue and the Role of Large-Scale Simulation
- J. Kozloski
- 3 May 2011
The brain implements a myriad of global brain functions to support adaptive behaviors, and variation and recombination of familiar structuralelements of the brain generate tissue-level functions that yield distinct tissues derived from stationary statistical combina-tions of a variety of neuron and synapse types in space, which is defined as microcircuitry.
Striatal Network Models of Huntington's Disease Dysfunction Phenotypes
It is found that randomly initialized networks often show dynamics more resembling “winner-take-all,” and relate this “unhealthy” model activity to dysfunctional physiological and anatomical phenotypes in the striatum of Huntington's disease animal models.