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Crucial role of p53-dependent cellular senescence in suppression of Pten-deficient tumorigenesis
TLDR
It is shown that conditional inactivation of Trp53 in the mouse prostate fails to produce a tumour phenotype, whereas complete Pten inactivation in the prostate triggers non-lethal invasive prostate cancer after long latency, and support a model for cooperative tumour suppression in which p53 is an essential failsafe protein of Pten-deficient tumours. Expand
Reciprocal feedback regulation of PI3K and androgen receptor signaling in PTEN-deficient prostate cancer.
TLDR
Combined pharmacologic inhibition of PI3K and AR signaling caused near-complete prostate cancer regressions in a Pten-deficient murine prostate cancer model and in human prostate cancer xenografts, indicating that both pathways coordinately support survival. Expand
Pten Dose Dictates Cancer Progression in the Prostate
TLDR
The results provide conclusive genetic support for the notion that PTEN is haploinsufficient in tumor suppression and that its dose is a key determinant in cancer progression. Expand
Identification of a tumour suppressor network opposing nuclear Akt function
TLDR
It is demonstrated that Pml orchestrates a nuclear tumour suppressor network for inactivation of nuclear pAkt, and thus highlights the importance of AKT compartmentalization in human cancer pathogenesis and treatment. Expand
Towards multidimensional radiotherapy (MD-CRT): biological imaging and biological conformality.
TLDR
The concept of integrating physical and biological conformality in multidimensional conformal radiotherapy (MD-CRT) is explored and the concept of "biological target volume" (BTV) is proposed and hypothesized that BTV can be derived from biological images and that their use may incrementally improve target delineation and dose delivery. Expand
Dual targeting of EGFR can overcome a major drug resistance mutation in mouse models of EGFR mutant lung cancer.
TLDR
Surprisingly, it was found that only the combination of both agents together induced dramatic shrinkage of erlotinib-resistant tumors harboring the T790M mutation, because together they efficiently depleted both phosphorylated and total EGFR. Expand
Phase I study of intravenous vascular endothelial growth factor trap, aflibercept, in patients with advanced solid tumors.
TLDR
VEGF Trap was well tolerated at the dose levels tested and pharmacodynamic and pharmacokinetic markers were indicative of VEGF blockade, and the recommended phase II dose is 4 mg/kg every 2 weeks. Expand
Dose-Dependent Effects of Platelet-Derived Growth Factor-B on Glial Tumorigenesis
TLDR
The data show that PDGFR signaling quantitatively regulates tumor grade and is required to sustain high-grade oligodendrogliomas. Expand
Correlation of proton MR spectroscopic imaging with gleason score based on step-section pathologic analysis after radical prostatectomy.
TLDR
MR spectroscopic imaging measurement of prostate tumor (Cho + Cr)/Cit and tumor volume correlate with pathologic Gleason score and has potential in noninvasive assessment of prostate cancer aggressiveness. Expand
Dynamic contrast-enhanced magnetic resonance imaging as a predictor of outcome in head-and-neck squamous cell carcinoma patients with nodal metastases.
TLDR
It is shown that skewness of K(trans) was the strongest predictor of PFS and OS in Stage IV HNSCC patients with nodal disease, suggesting an important role for pretreatment DCE-MRI parameter K( trans) as a predictor of outcome in these patients. Expand
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