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Differential expression of vascular smooth muscle-modulating microRNAs in human peripheral blood mononuclear cells: novel targets in essential hypertension
Vascular smooth muscle cell (VSMC) phenotypic plasticity has a critical role in the pathophysiology of arterial remodeling in essential hypertension. MicroRNAs are emerging as potential biomarkersExpand
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MicroRNA-9 and microRNA-126 expression levels in patients with essential hypertension: potential markers of target-organ damage.
MicroRNAs (miRs), as essential gene expression regulators, modulate cardiovascular development and disease and thus they are emerging as potential biomarkers and therapeutic targets in cardiovascularExpand
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Low Levels of MicroRNA‐21 Are a Marker of Reduced Arterial Stiffness in Well‐Controlled Hypertension
MicroRNAs (miRNAs) play a crucial role in myocardial and vascular remodeling and have emerged as potential diagnostic and prognostic biomarkers or as therapeutic targets. The authors aimed toExpand
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MicroRNAs in Peripheral Mononuclear Cells as Potential Biomarkers in Hypertensive Patients With Heart Failure With Preserved Ejection Fraction
BACKGROUND MicroRNAs (miRs) regulate gene expression and play an important role in ventricular and vascular remodeling. However, there are limited data regarding their role in heart failure withExpand
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TLR2 and TLR4 Gene Expression in Peripheral Monocytes in Nondiabetic Hypertensive Patients: The Effect of Intensive Blood Pressure–Lowering
J Clin Hypertens (Greenwich). 2012; 14:330–335. ©2012 Wiley Periodicals, Inc.
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Biochemical characterisation of Troponin C mutations causing hypertrophic and dilated cardiomyopathies
Cardiac muscle contraction occurs through an interaction of the myosin head with the actin filaments, a process which is regulated by the troponin complex together with tropomyosin and is Ca2+Expand
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Early cardiac gene transcript levels in peripheral blood mononuclear cells in patients with untreated essential hypertension
Objectives To assess the expression of early cardiac genes, implicated in the hypertrophic growth response of the adult heart, in peripheral blood mononuclear cells in patients with essentialExpand
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Blockade of platelet alpha2B-adrenergic receptors: a novel antiaggregant mechanism.
BACKGROUND Platelets play a vital role in hemostasis and thrombosis. Catecholamines have a profound effect on platelet aggregation and atherothrombosis but the exact mechanism involved isExpand
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Hypertrophic and antihypertrophic microRNA levels in peripheral blood mononuclear cells and their relationship to left ventricular hypertrophy in patients with essential hypertension.
MicroRNAs regulate several aspects of physiological and pathologic cardiac hypertrophy, and they represent promising therapeutic targets in cardiovascular disease. We assessed the expression levelsExpand
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Platelet microRNAs in hypertensive patients with and without cardiovascular disease
Platelets contain abundant microRNAs (miRs) that regulate gene expression and protein synthesis and may reflect platelet activation. We assessed platelet levels of miR-223, miR-126, and miR-22 in 82Expand
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