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Neuroinflammation in Alzheimer's disease
Tetracyclines inhibit microglial activation and are neuroprotective in global brain ischemia.
The results suggest that lipid-soluble tetracyclines, doxycycline and minocycline, inhibit inflammation and are neuroprotective against ischemic stroke, even when administered after the insult.
A tetracycline derivative, minocycline, reduces inflammation and protects against focal cerebral ischemia with a wide therapeutic window.
It is shown that daily treatment with minocycline reduces cortical infarction volume by 76 +/- 22% when the treatment is started 12 h before ischemia and by 63 +/- 35% when started even 4 h after the onset of ischemian, suggesting minocyCline may represent a prototype of an antiinflammatory compound that provides protection against ischemic stroke and has a clinically relevant therapeutic window.
Minocycline, a Tetracycline Derivative, Is Neuroprotective against Excitotoxicity by Inhibiting Activation and Proliferation of Microglia
The findings indicate that the proliferation and activation of microglia contributes to excitotoxicity, which is inhibited by minocycline, an antibiotic used in severe human infections.
Minocycline Provides Neuroprotection Against N-Methyl-d-aspartate Neurotoxicity by Inhibiting Microglia1
It is suggested that microglial activation contributes to NMDA excitotoxicity and that minocycline, a tetracycline derivative, represents a potential therapeutic agent for brain diseases.
Role of p38 and p44/42 mitogen‐activated protein kinases in microglia
In vivo evidence is described implicating that p38 and p44/42 MAPKs may play a critical role in harmful microglial activation in acute brain injury, such as stroke, and in more chronic neurodegenerative diseases,such as Alzheimer's disease.
Hypermethylation of the APC (adenomatous Polyposis Coli) gene promoter region in human colorectal carcinoma
It is shown that the promoter region of the APC gene is heavily methylated at CpG sites in patients with colorectal carcinoma in comparison with normal colonic mucosa and premalignant adenomas, suggesting that cytosine methylation of the regulatory sequences of theAPC gene could be involved in the progression of human coloreCTal cancer.
Nuclear Factor-&kgr;B Contributes to Infarction After Permanent Focal Ischemia
NF-&kgr;B is induced in neurons during human stroke, and activation of NF- &k Gr;B in the brain may contribute to infarction in pMCAO.