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- Publications
- Influence
Determination of kinetic constants for peptidyl prolyl cis-trans isomerases by an improved spectrophotometric assay.
- J. Kofron, P. Kuzmič, V. Kishore, E. Colon-Bonilla, D. Rich
- Chemistry, Medicine
- Biochemistry
- 1 November 1991
The kinetic properties and substrate specificity of two well-characterized peptidyl prolyl cis-trans isomerases (PPIases), cyclophilin and the FK-506 binding protein (FKBP), have been previously… Expand
Distinctive roles of PHAP proteins and prothymosin-alpha in a death regulatory pathway.
A small molecule, alpha-(trichloromethyl)-4-pyridineethanol (PETCM), was identified by high-throughput screening as an activator of caspase-3 in extracts of a panel of cancer cells. PETCM was used in… Expand
Do structurally similar molecules have similar biological activity?
- Y. C. Martin, J. Kofron, L. Traphagen
- Chemistry, Medicine
- Journal of medicinal chemistry
- 13 August 2002
To design diverse combinatorial libraries or to select diverse compounds to augment a screening collection, computational chemists frequently reject compounds that are > or =0.85 similar to one… Expand
Distinctive Roles of PHAP Proteins and Prothymosin-α in a Death Regulatory Pathway
A small molecule, α-(trichloromethyl)-4-pyridineethanol (PETCM), was identified by high-throughput screening as an activator of caspase-3 in extracts of a panel of cancer cells. PETCM was used in… Expand
Determination of kinetic constants for peptidyl prolyl cis-trans isomerases by an improved spectrophotometric assay.
- J. Kofron, P. Kuzmič, V. Kishore, E. Colon-Bonilla, D. Rich
- Chemistry
- 25 June 1991
The kinetic properties and substrate specificity of two well-characterized peptidyl prolyl cis-trans isomerases (PPIases), cyclophilin and the FK-506 binding protein (FKBP), have been previously… Expand
Lithium chloride perturbation of cis-trans peptide bond equilibria: effect on conformational equilibria in cyclosporin A and on time-dependent inhibition of cyclophilin
- J. Kofron, P. Kuzmič, V. Kishore, G. Gemmecker, S. Fesik, D. Rich
- Chemistry
- 1 March 1992
The cyclic undecapeptide cyclosporin A (CsA) is a slow-binding inhibitor of the peptidylprolyl cis-trans isomerase (PPIase) cyclophiiin. Both the initial inhibitory activity and the subsequent… Expand
Identification of actin and HSP 70 as cyclosporin A binding proteins by photoaffinity labeling and fluorescence displacement assays.
- M. Moss, R. Palmer, +6 authors D. Rich
- Chemistry, Medicine
- The Journal of biological chemistry
- 5 November 1992
A novel family of cyclosporin A (CsA) binding proteins was identified by using the biologically active, radioiodinated photoaffinity probe [D-Lys-N… Expand
Microarrayed Compound Screening (μARCS) to Identify Activators and Inhibitors of AMP-Activated Protein Kinase
- S. N. Anderson, B. Cool, +8 authors D. Burns
- Biology, Medicine
- Journal of biomolecular screening
- 1 March 2004
A novel and innovative high-throughput screening assay was developed to identify both activators and inhibitors of AMP-activated protein kinase (AMPK) using microarrayed compound screening (μARCS)… Expand
Microarray Compound Screening (μARCS) to Identify Inhibitors of HIV Integrase
- C. David, T. Middleton, +7 authors D. Burns
- Biology
- 1 June 2002
A novel high-throughput strand transfer assay has been developed, using Microarray Compound Screening (μARCS) technology, to identify inhibitors of human immunodeficiency virus (HIV) integrase. This… Expand
Substrate activity of synthetic formyl phosphate in the reaction catalyzed by formyltetrahydrofolate synthetase.
- G. Smithers, H. Jahansouz, J. Kofron, R. Himes, G. H. Reed
- Chemistry, Medicine
- Biochemistry
- 30 June 1987
Formyl phosphate, a putative enzyme-bound intermediate in the reaction catalyzed by formyltetrahydrofolate synthetase (EC 6.3.4.3), was synthesized from formyl fluoride and inorganic phosphate… Expand