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Wegener's granulomatosis with renal involvement: patient survival and correlations between initial renal function, renal histology, therapy and renal outcome.
The major cause of renal functional impairment was relapse of Wegener's granulomatosis usually within 2 years after clinical remission, therefore prolonged treatment with cyclophosphamide for at least 2 yearsafter clinical remission is recommended.
Detection and clinical implication of anti-neutrophil cytoplasm antibodies in Wegener's granulomatosis and rapidly progressive glomerulonephritis.
Different staining patterns of neutrophils which are related to different clinical entities within the spectrum of small vessel vasculitis are demonstrated, pointing out that different antigens are involved in the various types of Vasculitis.
Mechanism of Cephalosporin‐induced Hypoprothrombinemia: Relation to Cephalosporin Side Chain, Vitamin K Metabolism, and Vitamin K Status
The data suggest that NMTT‐cephalosporins are inhibitors of hepatic vitamin K epoxide reductase and that a lower nutritional‐vitamin K status predisposes to hypoprothrombinemia.
Antineutrophil-cytoplasmic antibodies and antiglomerular basement membrane antibodies in Goodpasture's syndrome and in Wegener's granulomatosis.
The clinical prognosis of patients withAntiglomerular basement membrane (anti-GBM) diseases-including Goodpasture's (GP) syndrome-and Wegener's granulomatosis (WG) was similar to that of those patients who lacked these antibodies; in addition, the clinical prog outlook of these patients was similarTo that of the patients who lack these antibodies.
Evidence for impaired hepatic vitamin K1 metabolism in patients treated with N-methyl-thiotetrazole cephalosporins.
In 8 patients on no oral intake and with parenteral alimentation, administration of cephalosporins with N-methyl-thiotetrazole side chain (moxalactam, cefamandole), was associated with prolongation