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Vancomycin resistance: structure of D-alanine:D-alanine ligase at 2.3 A resolution.
The molecular structure of the D-alanine:D-alanine ligase of the ddlB gene of Escherichia coli, co-crystallized with an S,R-methylphosphinate and adenosine triphosphate, was determined by x-rayExpand
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Extended-spectrum and inhibitor-resistant TEM-type beta-lactamases: mutations, specificity, and three-dimensional structure.
  • J. Knox
  • Biology, Medicine
  • Antimicrobial agents and chemotherapy
  • 1 December 1995
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Crystallographic structure of a phosphonate derivative of the Enterobacter cloacae P99 cephalosporinase: mechanistic interpretation of a beta-lactamase transition-state analog.
The crystal structure of a complex formed on reaction of the Enterobacter cloacae P99 cephalosporinase (beta-lactamase) with a phosphonate monoester inhibitor, m-carboxyphenylExpand
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Evolution of an enzyme activity: crystallographic structure at 2-A resolution of cephalosporinase from the ampC gene of Enterobacter cloacae P99 and comparison with a class A penicillinase.
The structure of the class C ampC beta-lactamase (cephalosporinase) from Enterobacter cloacae strain P99 has been established by x-ray crystallography to 2-A resolution and compared to a class AExpand
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Comparison of β‐lactamases of classes A and D: 1.5‐Å crystallographic structure of the class D OXA‐1 oxacillinase
The crystallographic structure of the Escherichia coli OXA‐1 β‐lactamase has been established at 1.5‐Å resolution and refined to R = 0.18. The 28.2‐kD oxacillinase is a class D serine β‐lactamaseExpand
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Molecular evolution of bacterial β-lactam resistance
BACKGROUND: Two groups of penicillin-destroying enzymes, the class A and class C beta-lactamases, may have evolved from bacterial transpeptidases that transfer X-D-Ala-D-Ala peptides to the growingExpand
  • 93
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Structure of the SHV-1 beta-lactamase.
The X-ray crystallographic structure of the SHV-1 beta-lactamase has been established. The enzyme crystallizes from poly(ethylene glycol) at pH 7 in space group P212121 with cell dimensions a = 49.6Expand
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Ultrahigh resolution structure of a class A beta-lactamase: on the mechanism and specificity of the extended-spectrum SHV-2 enzyme.
Bacterial beta-lactamases hydrolyze beta-lactam antibiotics such as penicillins and cephalosporins. The TEM-type class A beta-lactamase SHV-2 is a natural variant that exhibits activity againstExpand
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The three-dimensional structure of ribonuclease-S. Interpretation of an electron density map at a nominal resolution of 2 A.
Abstract The procedures used in the collection and analysis of x-ray diffraction data from single crystals of ribonuclease-S are described. Both isomorphous and anomalous scattering were measured onExpand
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