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Antineoplastic agents. 545. Isolation and structure of turbostatins 1-4 from the Asian marine mollusk Turbo stenogyrus.
The cancer cell line bioassay-guided separation of an extract from the marine mollusk Turbo stenogyrus led to the isolation of four new cerebrosides designated turbostatins 1-4 (1-4), which exhibited significant cancer cell growth inhibition against the murine P388 lymphocytic leukemia and a panel of human cancer cell lines. Expand
Antineoplastic agents. 534. isolation and structure of sansevistatins 1 and 2 from the African Sansevieria ehrenbergii.
Most of the saponins exhibited antimicrobial activity, particularly against the pathogenic fungi Candida albicans and Cryptococcus neoformans and in addition, most were found to cause inhibition of cancer cell growth. Expand
Bioconversion of sitosterol to useful steroidal intermediates by mutants of Mycobacterium fortuitum.
A series of mutants which have been isolated from the potent sterol degrader Mycobacterium fortuitum ATCC-6842 result in the accumulation of a number of intermediate compounds, some of which are potentially useful as substrates in the manufacture of medically important steroids. Expand
Isolation of labradorins 1 and 2 from Pseudomonas syringae pv. coronafaciens.
Investigation of Pseudomonas syringae pv. coronafaciens cancer cell growth inhibitory constituents led to the isolation of 2-isobutyl-5-(3-indolyl)oxazole (1) and 2-n-pentyl-5-(3-indolyl)oxazoleExpand
Isolation and structure of palstatin from the amazon tree Hymeneae palustris
Bioassay (P388 lymphocytic leukemia cell line and human cancer cell lines) guided separation of an extract prepared from the leaves of Hymenaea palustris Ducke led to the isolation of six cancer cellExpand
The cephalostatins. 21. Synthesis of bis-steroidal pyrazine rhamnosides (1).
Bis-steroidal pyrazines 10 and rhamnosides 17b and 21c were found to significantly inhibit cancer cell growth in a murine and human cancer cell line panel and inhibited growth of the nosocomial pathogen Enterococcus faecalis. Expand
Antibacterial activity of the marine sponge constituent cribrostatin 6.
Cribrostatin 6 is a promising lead antibiotic for Gram-positive bacteria, particularly S. pneumoniae, a leading cause of infection and mortality worldwide. Expand
Antineoplastic agents. 535. Isolation and structure of plakorstatins 1 and 2 from the Indo-Pacific sponge Plakortis nigra.
Two new cancer cell growth inhibiting cyclic peroxides, plakorstatins 1 (1) and 2 (2), were isolated from the Indonesian marine sponge Plakortis nigra and are the first plakortides with an epoxy group in the side chain. Expand
Antineoplastic agents. 550. Synthesis of 10b(s)-epipancratistatin from (+)-narciclasine.
Biological evaluation of 10b(S)-epipancratistatin provided evidence that antineoplastic activity was reduced by a factor of 10 when the B/C trans juncture was replaced with a B/B cis ring juncture. Expand