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Evidence-Based Approach for Interpretation of Epstein-Barr Virus Serological Patterns
TLDR
A large population of patients was used to develop evidence-based tools for interpreting EBV results and two easy-to-use tables were created to interpret EBV serological patterns based on whether three (EBV VCA IgG, IgM, and heterophile) or five markers are utilized. Expand
The structure of Cryptococcus neoformans galactoxylomannan contains beta-D-glucuronic acid.
TLDR
The structure of galactoxylomannan, a capsular polysaccharide from the opportunistic yeast Cryptococcus neoformans, was re-examined by NMR spectroscopy and GC-MS and a revised structure for this polymer is presented, along with a proposal that this compound be termed glucuronoxylmannogalactan (GXMGal). Expand
UDP-glucose Dehydrogenase Plays Multiple Roles in the Biology of the Pathogenic Fungus Cryptococcus neoformans*
TLDR
The capsule defect is largely independent of the other observed changes, as cells that are acapsular because of mutations in other genes show lack of virulence but do not exhibit alterations in cell integrity, temperature sensitivity, or cellular morphology. Expand
Evaluation of a Multiplexed Bead Assay for Assessment of Epstein-Barr Virus Immunologic Status
TLDR
There is excellent correlation between contemporary EBV serologic testing and the BioPlex 2200 system, and this approach potentially reduces overall cost, turnaround time, and sample volume. Expand
Cryptococcal Xylosyltransferase 1 (Cxt1p) from Cryptococcus neoformans Plays a Direct Role in the Synthesis of Capsule Polysaccharides*
TLDR
Deletion of CXT1 led to attenuation of cryptococcal growth in a mouse model of infection, suggesting that the affected xylose residues are important for normal host-pathogen interactions. Expand
A β-1,2-Xylosyltransferase from Cryptococcus neoformans Defines a New Family of Glycosyltransferases*
TLDR
A new family of glycosyltransferases, found exclusively within the fungal kingdom, is found within the genome sequence of C. neoformans and 34 within the sequences of other fungi, although none were found in other organisms. Expand
Identification and Deletion of Tft1, a Predicted Glycosyltransferase Necessary for Cell Wall β-1,3;1,4-Glucan Synthesis in Aspergillus fumigatus
TLDR
While the precise roles for β-(1,3;1,4)-glucan within A. fumigatus cell wall are still uncertain, it is clear that Tft1 plays a pivotal role in the biosynthesis of this cell wall polysaccharide. Expand
A Critical Appraisal of the Role of the Clinical Microbiology Laboratory in Diagnosis of Invasive Fungal Infections
TLDR
The goals of this session of Camp Clin Micro were to critically assess currently available methods and practices for diagnosing IFIs, to discuss the potential of current investigational methods, to evaluate the role of antifungal susceptibility testing, and to identify action items that can help move the field of diagnostic mycology in a direction that will improve the ability to identify IFIs in a timely manner. Expand
Glycosyltransferases and their products: cryptococcal variations on fungal themes.
TLDR
This article reviews the fungal glycosyltransferases that are involved in synthesis of the cell wall, the cryptococcal capsule, glycoproteins and glycolipids, and focuses on enzymes that have been identified or studied in C. neoformans. Expand
Evaluation of a home-based colorectal cancer screening intervention in a rural state.
TLDR
This low-intensity intervention of mailing FITs to average risk patients overdue for screening resulted in a significantly higher screening rate than educational materials alone or usual care, and may be of particular interest in rural areas. Expand
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