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Spatio-temporal regulation of circular RNA expression during porcine embryonic brain development
BackgroundRecently, thousands of circular RNAs (circRNAs) have been discovered in various tissues and cell types from human, mouse, fruit fly and nematodes. However, expression of circRNAs across… Expand
Comparison of circular RNA prediction tools
CircRNAs are novel members of the non-coding RNA family. For several decades circRNAs have been known to exist, however only recently the widespread abundance has become appreciated. Annotation of… Expand
MicroRNA-128 Governs Neuronal Excitability and Motor Behavior in Mice
Not Too Much, Not Too Little The microRNA miR128 is expressed in brain neurons of the mouse. Lek Tan et al. (p. 1254) now find that miR128 is crucial to stable brain function. Mice deficient in… Expand
The strength of the HIV-1 3' splice sites affects Rev function
- S. Kammler, M. Otte, I. Hauber, J. Kjems, J. Hauber, H. Schaal
- Biology, Medicine
- 4 December 2006
BackgroundThe HIV-1 Rev protein is a key component in the early to late switch in HIV-1 splicing from early intronless (e.g. tat, rev) to late intron-containing Rev-dependent (e.g. gag, vif, env)… Expand
Regulated HIV-2 RNA dimerization by means of alternative RNA conformations.
The dimer initiation site (DIS) hairpin of the HIV-2 untranslated leader RNA mediates in vitro dimerization through 'loop-loop kissing' of a loop-exposed palindrome sequence. Premature RNA… Expand
Circular RNAs in cancer: opportunities and challenges in the field
Circular RNA (circRNA) is a novel member of the noncoding cancer genome with distinct properties and diverse cellular functions, which is being explored at a steadily increasing pace. The list of… Expand
Mapping the RNA binding sites for human immunodeficiency virus type-1 gag and NC proteins within the complete HIV-1 and -2 untranslated leader regions.
Encapsidation of HIV-1 genomic RNA is mediated by specific interactions between the RNA packaging signal and the Gag protein. During maturation of the virion, the Gag protein is processed into… Expand
In Vitro Interaction between Human Immunodeficiency Virus Type 1 Rev Protein and Splicing Factor ASF/SF2-associated Protein, p32 (*)
- T. O. Tange, T. H. Jensen, J. Kjems
- Biology, Medicine
- The Journal of Biological Chemistry
- 26 April 1996
Continuous replication of human immunodeficiency virus type 1 requires the expression of the regulatory protein Rev, which binds to the Rev response element (RRE) and up-regulates the cytoplasmic… Expand
SF2/ASF binds to a splicing enhancer in the third HIV-1 tat exon and stimulates U2AF binding independently of the RS domain.
Splicing of a single HIV-1 primary transcript into more than 30 different mRNAs is regulated by a combination of suboptimal splice sites, cis-acting RNA splicing enhancers and silencers, and… Expand
Molecular strategies to inhibit HIV-1 replication
The human immunodeficiency virus type 1 (HIV-1) is the primary cause of the acquired immunodeficiency syndrome (AIDS), which is a slow, progressive and degenerative disease of the human immune… Expand