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Angiotensin subtype 1 blockade selectively potentiates adenosine subtype 2-mediated vasodilation.
TLDR
The data suggest that endogenous levels of angiotensin II, whether released locally or systemically, selectively attenuate the A2-mediated reductions in renal and mesenteric vascular resistances. Expand
Antiplatelet antibody [7E3 F(ab')2] prevents rethrombosis after recombinant tissue-type plasminogen activator-induced coronary artery thrombolysis in a canine model.
TLDR
The F(ab')2 fragment of the murine monoclonal antibody 7E3 to prevent rethrombosis after intracoronary clot lysis with recombinant tissue-type plasminogen activator (rt-PA) in an experimental model binds to the platelet glycoprotein IIb/ IIIa complex (GPIIb/IIIa), thereby preventing platelet-fibrinogen interaction and intravascular thrombus formation. Expand
Class III antiarrhythmic activity of novel substituted 4-[(methylsulfonyl)amino]benzamides and sulfonamides.
TLDR
Voltage-clamp studies in isolated myocytes show that 5 is a potent and specific blocker of the delayed rectifier potassium current (IK) at concentrations that cause significant prolongation of action potential duration. Expand
Cardiovascular pharmacology of the adenosine A1/A2-receptor agonist AMP 579: coronary hemodynamic and cardioprotective effects in the canine myocardium.
TLDR
Experimental results indicate that AMP 579 is an effective coronary vasodilator, which also can protect the heart from ischemic injury, and has the potential to be useful in cardiovascular therapeutics. Expand
Effects of the Positive Inotropic Agents Milrinone and Pimobendan on the Development of Lethal Ischemic Arrhythmias in Conscious Dogs with Recent Myocardial Infarction
TLDR
With both positive inotropic agents, including milrinone which may possess protective antithrombotic action, sudden death may be increased via a reduction in ventricular refractoriness in the ischemically injured heart. Expand
Potassium channel activators cromakalim and celikalim (WAY-120,491) fail to decrease myocardial infarct size in the anesthetized canine.
TLDR
Results of this study suggest that K-channel-activating drugs such as cromakalim and celikalim may not be effective agents in the acute therapeutic management of myocardial ischemic injury. Expand
[(3-aryl-1,2-benzisoxazol-6-yl)oxy]acetic acids. A new diuretic series.
TLDR
A series of [(3-aryl-1,2-benzisoxazol-6-yl)oxy]acetic acids was synthesized and tested for diuretic activity in saline-loaded mice and in conscious, water-loaded dogs, and compound 13ff, found to be moderately uricosuric in chimpanzees, was selected for further development. Expand
Hypothyroidism Renders Protection Against Lethal Ventricular Arrhythmias in a Conscious Canine Model of Sudden Death
TLDR
The lower incidence of PVS-induced VT and the development of spontaneous VF suggests that hypothyroidism renders protection from cardiac rhythm disturbance in the subacute phase of experimental myocardial infarction. Expand
Reduction in digitalis-associated postinfarction mortality with nadolol in conscious dogs.
TLDR
Acute beta-adrenoceptor blockade with nadolol appears to reduce digitalis-mediated ischemic postinfarction mortality, possibly because of a salutary increase in ventricular refractoriness. Expand
Pharmacology of 6,7-dihydroxy-2-dimethylaminotetralin (TL-99). I. Cardiovascular activity in the dog and cat.
TLDR
A detailed study of these compounds showed that they were most likely exerting their effects by inhibiting sympathetic nervous system activity. Expand
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