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Vascular Smooth Muscle Cell-derived, Gla-containing Growth-potentiating Factor for Ca-mobilizing Growth Factors (*)
TLDR
GPF specifically potentiated cell proliferation mediated by Ca-mobilizing receptors, suggesting that GPF may be a new type of extracellular factor regulating VSMC proliferation.
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Cell Adhesion to Phosphatidylserine Mediated by a Product of Growth Arrest-specific Gene 6*
TLDR
Findings suggest that Gas6 may play a role in recognition of cells exposing phosphatidylserine on their surfaces by phagocytic cells, which is supposed to be one of the mechanisms for clearing dying cells.
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Prevention of allergic inflammation by a novel prostaglandin receptor antagonist, S-5751.
TLDR
Oral administration of S-5751 alleviated allergen-induced plasma exudation in the conjunctiva in an allergic conjunctivitis model and antigen-induced eosinophil infiltration into the lung in an asthma model, suggesting that DP receptor antagonists may be useful in the treatment of allergic diseases triggered by mast cell activation.
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Requirement of gamma-carboxyglutamic acid residues for the biological activity of Gas6: contribution of endogenous Gas6 to the proliferation of vascular smooth muscle cells.
TLDR
It is shown that endogenously produced Gas6 is very important for VSMC proliferation induced by Ca2+-mobilizing growth factors, and the role of vitamin K-dependent modification of Gas6 in this regard is indicated.
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Pancreatic-type phospholipase A2 stimulates prostaglandin synthesis in mouse osteoblastic cells (MC3T3-E1) via a specific binding site.
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Development of a neutralizing antibody specific for the active form of matrix metalloproteinase-13.
TLDR
The highly selective MMP-13 neutralizing antibody (14D10) might be a useful tool for investigating the mechanism of type II collagen degradation in arthritic pathology.
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Molecular cloning of pancreatic group I phospholipase A2 receptor.
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Pancreatic-type phospholipase A2 induces group II phospholipase A2 expression and prostaglandin biosynthesis in rat mesangial cells.
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Kinetic studies on stereospecific recognition by the thromboxane A2/prostaglandin H2 receptor of the antagonist, S‐145
TLDR
The results suggest that it is at the stage of dissociation from the TXA2/PGH2 receptor that the stereochemistry of the optical isomers of S‐145 confers their difference in affinity for these receptors in rat VSMCs and human platelet membranes.
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Pharmacological characterization of prostaglandin-related ocular hypotensive agents
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