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- Publications
- Influence
Vascular Smooth Muscle Cell-derived, Gla-containing Growth-potentiating Factor for Ca-mobilizing Growth Factors (*)
- T. Nakano, K. Higashino, +5 authors H. Arita
- Biology, Medicine
- The Journal of Biological Chemistry
- 17 March 1995
Proliferation of vascular smooth muscle cells (VSMC) is triggered by two types of growth factors. One activates tyrosine kinase-type receptors and the other activates G-protein-coupled receptors. We… Expand
Cell Adhesion to Phosphatidylserine Mediated by a Product of Growth Arrest-specific Gene 6*
- T. Nakano, Y. Ishimoto, +6 authors H. Arita
- Biology, Medicine
- The Journal of Biological Chemistry
- 21 November 1997
Gas6, a product of a growth arrest-specific gene 6, potentiates proliferation of vascular smooth muscle cells and prevents cell death of vascular smooth muscle cells. It has been also demonstrated… Expand
Prevention of allergic inflammation by a novel prostaglandin receptor antagonist, S-5751.
- A. Arimura, K. Yasui, +5 authors H. Arita
- Medicine
- The Journal of pharmacology and experimental…
- 1 August 2001
Prostaglandin (PG) D2, the major cyclooxygenase metabolite generated from immunologically stimulated mast cells, is thought to contribute to the pathogenesis of allergic diseases due to its various… Expand
Pancreatic-type phospholipase A2 stimulates prostaglandin synthesis in mouse osteoblastic cells (MC3T3-E1) via a specific binding site.
- M. Tohkin, J. Kishino, J. Ishizaki, H. Arita
- Medicine, Biology
- The Journal of biological chemistry
- 5 February 1993
Previously, we have reported a novel proliferative action of pancreatic group I phospholipase A2 (PLA2-I) via a specific binding site in Swiss 3T3 fibroblasts, vascular smooth muscle cells, and… Expand
Requirement of gamma-carboxyglutamic acid residues for the biological activity of Gas6: contribution of endogenous Gas6 to the proliferation of vascular smooth muscle cells.
- T. Nakano, K. Kawamoto, J. Kishino, K. Nomura, K. Higashino, H. Arita
- Biology, Medicine
- The Biochemical journal
- 15 April 1997
Gas6 (encoded by growth-arrest-specific gene 6) is a gamma-carboxyglutamic acid (Gla)-containing protein which is released from growth-arrested vascular smooth muscle cells (VSMCs) and potentiates… Expand
Molecular cloning of pancreatic group I phospholipase A2 receptor.
- J. Ishizaki, K. Hanasaki, +4 authors H. Arita
- Medicine, Biology
- The Journal of biological chemistry
- 25 February 1994
We have recently reported that mammalian pancreatic group I phospholipase A2 (PLA2-I) has its specific receptor (PLA2 receptor) on a variety of mammalian cells and that various biological responses… Expand
Pancreatic-type phospholipase A2 induces group II phospholipase A2 expression and prostaglandin biosynthesis in rat mesangial cells.
- J. Kishino, O. Ohara, K. Nomura, R. Kramer, H. Arita
- Biology, Medicine
- The Journal of biological chemistry
- 18 February 1994
The effect of pancreatic group I phospholipase A2 (PLA2-I) on receptor-mediated expression of arthritic group II phospholipase A2 (PLA2-II) and its correlation with prostaglandin E2 (PGE2) synthesis… Expand
Kinetic studies on stereospecific recognition by the thromboxane A2/prostaglandin H2 receptor of the antagonist, S‐145
- J. Kishino, K. Hanasaki, Tohru Nagasaki, H. Arita
- Chemistry, Medicine
- British journal of pharmacology
- 1 August 1991
1 The mechanism for the stereospecific recognition of the antagonist S‐145 by the thromboxane A2 (TXA2)/prostaglandin H2 (PGH2) receptor was examined by ligand‐binding techniques in rat vascular… Expand
Pharmacological characterization of prostaglandin-related ocular hypotensive agents
- Y. Goh, J. Kishino
- Medicine
- 1994
- 43
- 1
Synthesis and biological activity of various derivatives of a novel class of potent, selective, and orally active prostaglandin D2 receptor antagonists. 1. Bicyclo[2.2.1]heptane derivatives.
- S. Mitsumori, T. Tsuri, +9 authors M. Ohtani
- Chemistry, Medicine
- Journal of medicinal chemistry
- 10 May 2003
Novel prostaglandin D(2) (PGD(2)) receptor antagonists were synthesized as a potential new class of antiallergic agents having a bicyclo[2.2.1]heptane ring system with sulfonamide groups. Some of… Expand