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Vascular Smooth Muscle Cell-derived, Gla-containing Growth-potentiating Factor for Ca-mobilizing Growth Factors (*)
GPF specifically potentiated cell proliferation mediated by Ca-mobilizing receptors, suggesting that GPF may be a new type of extracellular factor regulating VSMC proliferation.
Cell Adhesion to Phosphatidylserine Mediated by a Product of Growth Arrest-specific Gene 6*
- Toru Nakano, Y. Ishimoto, H. Arita
- Biology, ChemistryThe Journal of Biological Chemistry
- 21 November 1997
Findings suggest that Gas6 may play a role in recognition of cells exposing phosphatidylserine on their surfaces by phagocytic cells, which is supposed to be one of the mechanisms for clearing dying cells.
Prevention of allergic inflammation by a novel prostaglandin receptor antagonist, S-5751.
- A. Arimura, K. Yasui, H. Arita
- Medicine, BiologyThe Journal of pharmacology and experimental…
- 1 August 2001
Oral administration of S-5751 alleviated allergen-induced plasma exudation in the conjunctiva in an allergic conjunctivitis model and antigen-induced eosinophil infiltration into the lung in an asthma model, suggesting that DP receptor antagonists may be useful in the treatment of allergic diseases triggered by mast cell activation.
Requirement of gamma-carboxyglutamic acid residues for the biological activity of Gas6: contribution of endogenous Gas6 to the proliferation of vascular smooth muscle cells.
- T. Nakano, K. Kawamoto, J. Kishino, K. Nomura, K. Higashino, H. Arita
- Biology, ChemistryThe Biochemical journal
- 15 April 1997
It is shown that endogenously produced Gas6 is very important for VSMC proliferation induced by Ca2+-mobilizing growth factors, and the role of vitamin K-dependent modification of Gas6 in this regard is indicated.
Pancreatic-type phospholipase A2 stimulates prostaglandin synthesis in mouse osteoblastic cells (MC3T3-E1) via a specific binding site.
Development of a neutralizing antibody specific for the active form of matrix metalloproteinase-13.
The highly selective MMP-13 neutralizing antibody (14D10) might be a useful tool for investigating the mechanism of type II collagen degradation in arthritic pathology.
Molecular cloning of pancreatic group I phospholipase A2 receptor.
Pancreatic-type phospholipase A2 induces group II phospholipase A2 expression and prostaglandin biosynthesis in rat mesangial cells.
Kinetic studies on stereospecific recognition by the thromboxane A2/prostaglandin H2 receptor of the antagonist, S‐145
- J. Kishino, K. Hanasaki, T. Nagasaki, H. Arita
- Biology, ChemistryBritish journal of pharmacology
- 1 August 1991
The results suggest that it is at the stage of dissociation from the TXA2/PGH2 receptor that the stereochemistry of the optical isomers of S‐145 confers their difference in affinity for these receptors in rat VSMCs and human platelet membranes.