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Clearance of p16Ink4a-positive senescent cells delays ageing-associated disorders
Advanced age is the main risk factor for most chronic diseases and functional deficits in humans, but the fundamental mechanisms that drive ageing remain largely unknown, impeding the development of… Expand
Cellular senescence and the senescent secretory phenotype: therapeutic opportunities.
- T. Tchkonia, Y. Zhu, J. V. van Deursen, J. Campisi, J. Kirkland
- The Journal of clinical investigation
- 1 March 2013
Aging is the largest risk factor for most chronic diseases, which account for the majority of morbidity and health care expenditures in developed nations. New findings suggest that aging is a… Expand
The Achilles’ heel of senescent cells: from transcriptome to senolytic drugs
The healthspan of mice is enhanced by killing senescent cells using a transgenic suicide gene. Achieving the same using small molecules would have a tremendous impact on quality of life and the… Expand
Fat tissue, aging, and cellular senescence
Fat tissue, frequently the largest organ in humans, is at the nexus of mechanisms involved in longevity and age‐related metabolic dysfunction. Fat distribution and function change dramatically… Expand
Identification of inducible brown adipocyte progenitors residing in skeletal muscle and white fat
- T. Schulz, T. L. Huang, +12 authors Y. Tseng
- Biology, Medicine
- Proceedings of the National Academy of Sciences
- 20 December 2010
Brown fat is specialized for energy expenditure and has therefore been proposed to function as a defense against obesity. Despite recent advances in delineating the transcriptional regulation of… Expand
Mechanisms and metabolic implications of regional differences among fat depots.
Fat distribution is closely linked to metabolic disease risk. Distribution varies with sex, genetic background, disease state, certain drugs and hormones, development, and aging. Preadipocyte… Expand
Interdisciplinary inpatient care for elderly people with hip fracture: a randomized controlled trial.
- G. Naglie, C. Tansey, +6 authors B. Goldlist
- CMAJ : Canadian Medical Association journal…
- 9 July 2002
BACKGROUND Hip fractures in elderly people are associated with impaired function and ambulation and high rates of death and admission to institutions. Interventions designed to improve the outcomes… Expand
Cellular senescence mediates fibrotic pulmonary disease
- Marissa J. Schafer, T. White, +20 authors N. Lebrasseur
- Biology, Medicine
- Nature communications
- 23 February 2017
Idiopathic pulmonary fibrosis (IPF) is a fatal disease characterized by interstitial remodelling, leading to compromised lung function. Cellular senescence markers are detectable within IPF lung… Expand
Cellular Senescence: A Translational Perspective
Cellular senescence entails essentially irreversible replicative arrest, apoptosis resistance, and frequently acquisition of a pro-inflammatory, tissue-destructive senescence-associated secretory… Expand
Role of microRNA processing in adipose tissue in stress defense and longevity.
Excess adipose tissue is associated with metabolic disease and reduced life span, whereas caloric restriction decreases these risks. Here we show that as mice age, there is downregulation of Dicer… Expand