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Association of a functional variant downstream of TNFAIP3 with systemic lupus erythematosus
These results establish this TT>A variant as the most likely functional polymorphism responsible for the association between TNFAIP3 and SLE.
Chemical epigenetics alters the secondary metabolite composition of guttate excreted by an atlantic-forest-soil-derived Penicillium citreonigrum.
While guttate from control cultures exhibited a relatively simple assemblage of secondary metabolites, the Guttate collected from cultures treated with 50 muM 5-azacytidine was highly enriched in compounds representing at least three distinct biosynthetic families.
Role of glutathione S-transferase Pi in cisplatin-induced nephrotoxicity.
Waikialoid A suppresses hyphal morphogenesis and inhibits biofilm development in pathogenic Candida albicans.
A chemically prolific strain of Aspergillus was isolated from a soil sample collected near Waikiki Beach, Honolulu, Hawaii, and it was determined that one of the secondary metabolites from the Hawaiian fungal isolate, a new complex prenylated indole alkaloid named waikialoid A (1), inhibited biofilm formation with an IC(50) value of 1.4 μM.
Secondary metabolites produced by fungi derived from a microbial mat encountered in an iron-rich natural spring.
A Novel, Species-specific Class of Uncompetitive Inhibitors of γ-Glutamyl Transpeptidase*
- J. King, Matthew B West, P. Cook, M. Hanigan
- Biology, ChemistryJournal of Biological Chemistry
- 3 April 2009
A novel class of inhibitors of γ-glutamyl transpeptidase (GGT) is identified, providing the basis for further development of a new group of therapeutics that inhibit GGT by a mechanism distinct from the toxic glutamine analogues.
Fungal biofilm inhibitors from a human oral microbiome-derived bacterium.
- Xiaoru Wang, L. Du, J. You, J. King, R. Cichewicz
- Biology, ChemistryOrganic & biomolecular chemistry
- 16 February 2012
Three new analogues of mutanobactins B-D are characterized, found to inhibit biofilm formation by the fungal oral-pathogen Candida albicans, and the biosynthetic origins of this unique natural product family are determined.
Small-molecule suppressors of Candida albicans biofilm formation synergistically enhance the antifungal activity of amphotericin B against clinical Candida isolates.
Data suggest that the Candida biofilm disruption and amphotericin B potentiating effects of 3 and 4 could be mediated through multiple biological targets, and the shearinines are good tools for testing the potential advantages of using adjunctive therapies in combination with antifungals.
A Potent HDAC Inhibitor, 1-Alaninechlamydocin, from a Tolypocladium sp. Induces G2/M Cell Cycle Arrest and Apoptosis in MIA PaCa-2 Cells
- L. Du, A. L. Risinger, J. King, D. Powell, R. Cichewicz
- Biology, ChemistryJournal of natural products
- 7 July 2014
1-Alaninechlamydocin showed potent antiproliferative/cytotoxic activities in a human pancreatic cancer cell line (MIA PaCa-2) at low-nanomolar concentrations and induced G2/M cell cycle arrest and apoptosis.
Chlorinated Polyketide Obtained from a Daldinia sp. Treated with the Epigenetic Modifier Suberoylanilide Hydroxamic Acid
During the course of these studies it was determined that metabolite 2 and the previously reported daldinone B shared the same spectroscopic data, leading to a revision of the reported structure.