Share This Author
Genomic and structural analysis of Syn9, a cyanophage infecting marine Prochlorococcus and Synechococcus.
Experimental and computational analyses identified genes likely involved in virion formation, nucleotide synthesis, and DNA replication and repair in Syn9 that suggest that Syn9 is well adapted to the physiology of its photosynthetic hosts and may affect the evolution of these sequences within marine cyanobacteria.
Structure of epsilon15 bacteriophage reveals genome organization and DNA packaging/injection apparatus
The shell protein from icosahedral reconstruction at higher resolution exhibits a similar fold to that of other double-stranded DNA viruses including herpesvirus, suggesting a common ancestor among these diverse viruses.
Structural basis for scaffolding-mediated assembly and maturation of a dsDNA virus
- Dong-Hua Chen, M. Baker, W. Chiu
- Biology, ChemistryProceedings of the National Academy of Sciences
- 10 January 2011
Structural observations allow us to propose a more detailed molecular mechanism for the scaffolding-mediated capsid assembly initiation including portal incorporation, release of scaffolding proteins upon DNA packaging, and maturation into infectious virions.
Backbone structure of the infectious ε15 virus capsid revealed by electron cryomicroscopy
- Wen Jiang, M. Baker, J. Jakana, P. Weigele, J. King, W. Chiu
- Chemistry, BiologyNature
- 28 February 2008
The 4.5-Å resolution structure of a 22-MDa macromolecular assembly, the capsid of the infectious epsilon15 (ε15) particle, by single-particle electron cryomicroscopy is reported, which reveals a similar protein architecture to that of other tailed double-stranded DNA viruses, even in the absence of detectable sequence similarity.
Mechanism of head assembly and DNA encapsulation in Salmonella phage p22. I. Genes, proteins, structures and DNA maturation.
betawrap: Successful prediction of parallel β-helices from primary sequence reveals an association with many microbial pathogens
- Phil Bradley, L. Cowen, Matthew Menke, J. King, B. Berger
- BiologyProceedings of the National Academy of Sciences…
- 18 December 2001
A computational approach is presented that predicts the right-handed parallel β-helix supersecondary structural motif in primary amino acid sequences by using β-strand interactions learned from non-β-helIX structures to generate interstrand pairwise correlations from a processive sequence wrap.
Protein misfolding and aggregation in cataract disease and prospects for prevention.
Three-dimensional transformation of capsids associated with genome packaging in a bacterial virus.
Three-dimensional structures of the empty procapsid and the mature capsid of the Salmonella bacteriophage P22 have been determined to a resolution of 28 A using electron cryomicroscopy and computer image processing to indicate extensive structural changes take place during maturation in all seven quasi-equivalent subunits.
Polypeptides of the tail fibres of bacteriophage T4.