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Oxidant stress-induced loss of IRS-1 and IRS-2 proteins in rat skeletal muscle: role of p38 MAPK.
Oxidative stress is characterized as an imbalance between the cellular production of oxidants and the cellular antioxidant defenses and contributes to the development of numerous cardiovascular andExpand
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Oxidant stress and skeletal muscle glucose transport: roles of insulin signaling and p38 MAPK.
Oxidative stress can impact the regulation of glucose transport activity in a variety of cell lines. In the present study, we assessed the direct effects of an oxidant stress on the glucose transportExpand
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Critical role of the transient activation of p38 MAPK in the etiology of skeletal muscle insulin resistance induced by low-level in vitro oxidant stress.
Increased cellular exposure to oxidants may contribute to the development of insulin resistance and type 2 diabetes. Skeletal muscle is the primary site of insulin-dependent glucose disposal in theExpand
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Potentiation of PGE2‐mediated cAMP production during neuronal differentiation of human neuroblastoma SK‐N‐BE(2)C cells
The prostaglandin‐evoked cAMP production was studied in human neuroblastoma SK‐N‐BE(2)C cells during neuronal differentiation induced by all‐trans retinoic acid. The incubation with 5 µm all‐transExpand
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Selective angiotensin II receptor antagonism enhances whole-body insulin sensitivity and muscle glucose transport in hypertensive TG(mREN2)27 rats.
Essential hypertension is frequently associated with insulin resistance of skeletal muscle glucose transport, and angiotensin II (ANGII) can contribute to the pathogenesis of both conditions. TheExpand
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Effects of compensatory growth on the expression of milk protein gene and biochemical changes of the mammary gland in Holstein cows
Abstract Twenty-four Holstein heifers were randomly assigned to either a control or test group to investigate effects of an incremental growth pattern on the development and differentiation of theExpand
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Loss of Blood-Brain Barrier Integrity in a KCl-Induced Model of Episodic Headache Enhances CNS Drug Delivery
Abstract Cortical spreading depression (CSD) in the CNS is suggested as a common mechanism contributing to headache. Despite strong evidence for CNS involvement in headache disorders, drugExpand
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WORLD'S FIRST RECYCLED PLASTIC BRIDGES
According to the Federal Highway Administration's (FHWA) National Bridge Inventory, one third of nearly 600,000 U.S. highway bridges are classified as structurally deficient or functionally obsolete.Expand
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World's First Thermoplastic Bridges made of Recycled Plastics
Deterioration of bridges has been well recognized throughout the world. The estimated repair and replacement cost is $229 billion for the U.S. highway bridges alone. Recently an innovativeExpand
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