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A phase I/II study to evaluate the toxicity and efficacy of accelerated fractionation radiotherapy for the palliation of dysphagia from carcinoma of the oesophagus.
AIMS We hypothesised that accelerated fractionated radiotherapy may provide a good palliative approach for dysphagia relief in patients with incurable oesophageal cancer, significantly reducing theExpand
Post-operative radiochemotherapy for gastric cancer: adoption and adaptation.
AIMS Intergroup study 0116 (INT-0116) showed an 11% absolute improvement in 3-year survival with post-operative radiochemotherapy for gastric cancer, but reported 33% severe acute GI toxicity usingExpand
Evaluating the impact on quality of life of chemoradiation in gastric cancer.
OBJECTIVE Our phase I study prospectively evaluated quality of life (QOL) in patients undergoing adjuvant chemoradiation for gastric adenocarcinoma. METHODS Thirty-three patients receivingExpand
Adjuvant chemoradiation for gastric cancer with infusional 5-fluorouracil and cisplatin: a phase I study.
OBJECTIVE This phase I study aimed to determine the maximal tolerated dose of cisplatin administered every 2 weeks with infusional 5-fluorouracil (5FU) and concurrent radiation therapy (RT) inExpand
PO-277 Single-cell RNA-seq analysis of human pancreatic ductal adenocarcinoma
Introduction Pancreatic Ductal Adenomcarcinoma (PDAC) is one of the most lethal forms of cancer with a five-year survival rate of 8%. Genetic alterations such as activating mutations in KRAS andExpand