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Pegylated poly-l-arginine derivatives of chitosan for effective delivery of siRNA.
- S. Noh, M. O. Park, +10 authors Yu-Kyoung Oh
- Chemistry, Medicine
- Journal of controlled release : official journal…
- 14 July 2010
For delivery of siRNA, chitosan (CS) was derivatized with poly-l-arginine (PLR) and polyethylene glycol (PEG). The formation of polyplexes with siRNA was confirmed by gel retardation. The PLR-grafted… Expand
Probing biomolecule recognition with electron transfer: electrochemical sensors for DNA hybridization.
- M. Napier, Carson R. Loomis, M. F. Sistare, J. Kim, A. Eckhardt, H. H. Thorp
- Medicine, Chemistry
- Bioconjugate chemistry
- 1 November 1997
Identifying infectious organisms, quantitating gene expression, and sequencing genomic DNA on chips all rely on the detection of nucleic acid hybridization. Described here is a novel assay for… Expand
Analysis on Protection Coordination of Hybrid SFCL With Protective Devices in a Power Distribution System
In this paper, the experimental devices to simulate the operation of the hybrid SFCL as well as the protection coordination between the protective devices such as the over-current relay (OCR) were constructed and analysed through the experiments. Expand
Rapid detection of Listeria monocytogenes by real-time PCR in processed meat and dairy products.
The objectives of this study were to evaluate the detection of Listeria monocytogenes in different ready-to-eat foods using real-time PCR (RT-PCR). Various concentrations (10(0) to 10(5) CFU/ml) of… Expand
Enhancement of DC vaccine potency by activating the PI3K/AKT pathway with a small interfering RNA targeting PTEN.
Dendritic cell (DC)-based cancer vaccines have become important as an immunotherapeutics in generating anti-tumor immune responses. Due to a short lifespan of DCs, however, clinical application of… Expand
Liposomal drug delivery system
- J. Kim
- Journal of Pharmaceutical Investigation
- 20 May 2016
Lipid-based self-assembling vesicles were first described in 1961 and reported in 1964 by Dr. Alec D. Bangham (Bangham and Horne in J Mol Biol 8:660–668, 1964) at the Babraham Institute in Cambridge,… Expand
Plasmid vectors harboring cellular promoters can induce prolonged gene expression in hematopoietic and mesenchymal progenitor cells.
- Hyang-Min Byun, D. Suh, +7 authors Yu-Kyoung Oh
- Medicine, Biology
- Biochemical and biophysical research…
- 1 July 2005
Although prolonged transgene expression in progenitor cells might be desirable for modified cell therapy, the viral promoter-based expression vector tends to promote transgene expression only for a… Expand
A Clinical Observation of Drug Hypersensitivity Syndrome and Serologic and Molecular Genetic Analyses of Human Herpesvirus-6 Reactivation
Upregulation of NAD(P)H:quinone oxidoreductase by radiation potentiates the effect of bioreductive beta-lapachone on cancer cells.
We found that beta-lapachone (beta-lap), a novel bioreductive drug, caused rapid apoptosis and clonogenic cell death in A549 human lung epithelial cancer cells in vitro in a dose-dependent manner.… Expand
pH-Responsive PEG-Poly(β-amino ester) Block Copolymer Micelles with a Sharp Transition
Summary: A pH-sensitive block copolymer is synthesized by step polymerization and its pH-sensitive micellization-demicellization behavior is studied. This polymer has a hydrophilic MPEG (shell) and… Expand