• Publications
  • Influence
Nogo Receptor Antagonism Promotes Stroke Recovery by Enhancing Axonal Plasticity
After ischemic stroke, partial recovery of function frequently occurs and may depend on the plasticity of axonal connections. Here, we examine whether blockade of the Nogo-NogoReceptor (NgR) pathwayExpand
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Regulation of Neurogenesis in Adult Mouse Hippocampus by cAMP and the cAMP Response Element-Binding Protein
The cAMP cascade, including the cAMP response element-binding protein (CREB), is known to play an important role in neuronal survival and plasticity. Here the influence of this cascade onExpand
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Nogo-66 Receptor Prevents Raphespinal and Rubrospinal Axon Regeneration and Limits Functional Recovery from Spinal Cord Injury
Axon regeneration after injury to the adult mammalian CNS is limited in part by three inhibitory proteins in CNS myelin: Nogo-A, MAG, and OMgp. All three of these proteins bind to a Nogo-66 receptorExpand
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Rec8 phosphorylation and recombination promote the step-wise loss of cohesins in meiosis
During meiosis, cohesins—protein complexes that hold sister chromatids together—are lost from chromosomes in a step-wise manner. Loss of cohesins from chromosome arms is necessary for homologousExpand
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Localization of Phosphorylated cAMP Response Element-Binding Protein in Immature Neurons of Adult Hippocampus
Neurogenesis continues to occur in the adult hippocampus, although many of the newborn cells degenerate 1–2 weeks after birth. The number and survival of newborn cells are regulated by a variety ofExpand
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Axon Regeneration in Young Adult Mice Lacking Nogo-A/B
After injury, axons of the adult mammalian brain and spinal cord exhibit little regeneration. It has been suggested that axon growth inhibitors, such as myelin-derived Nogo, prevent CNS axon repair.Expand
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Genetic Variants of Nogo-66 Receptor with Possible Association to Schizophrenia Block Myelin Inhibition of Axon Growth
In schizophrenia, genetic predisposition has been linked to chromosome 22q11 and myelin-specific genes are misexpressed in schizophrenia. Nogo-66 receptor 1 (NGR or RTN4R) has been considered to be aExpand
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Purification and characterization of fibrinolytic enzyme from cultured mycelia of Armillaria mellea.
  • S. Lee, J. Kim, +8 authors S. Kim
  • Medicine, Chemistry
  • Protein expression and purification
  • 1 September 2005
A fibrinolytic enzyme was purified from the cultured mycelia of Armillaria mellea by ion-exchange chromatography followed by gel filtration, and was designated A. mellea metalloprotease (AMMP). TheExpand
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Investigating synapse formation and function using human pluripotent stem cell-derived neurons
A major goal of stem-cell research is to identify conditions that reliably regulate their differentiation into specific cell types. This goal is particularly important for human stem cells if theyExpand
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Epileptogenic roles of astroglial death and regeneration in the dentate gyrus of experimental temporal lobe epilepsy
Recent studies have demonstrated that blockade of neuronal death in the hippocampus cannot prevent epileptogenesis in various epileptic models. These reports indicate that neurodegeneration alone isExpand
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