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IL-17 induces production of IL-6 and IL-8 in rheumatoid arthritis synovial fibroblasts via NF-κB- and PI3-kinase/Akt-dependent pathways
Recent studies of the pathogenesis of rheumatoid arthritis (RA) have revealed that both synovial fibroblasts and T cells participate in the perpetuation of joint inflammation as dynamic partners in aExpand
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Tensile and compressive behavior of tungsten, molybdenum, tantalum and niobium at the nanoscale
In situ nanomechanical tests are carried out to investigate the tensile and compressive behavior of -oriented body-centered cubic (bcc) metals W, Mo, Ta and Nb with nanometer dimensions. We find thatExpand
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Statistics of dislocation slip avalanches in nanosized single crystals show tuned critical behavior predicted by a simple mean field model.
We show that slowly sheared metallic nanocrystals deform via discrete strain bursts (slips), whose size distributions follow power laws with stress-dependent cutoffs. We show for the first time thatExpand
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Engineered polymeric nanoparticles for soil remediation.
Hydrophobic organic groundwater contaminants, such as polynuclear aromatic hydrocarbons (PAHs), sorb strongly to soils and are difficult to remove. We report here on the synthesis of amphiphilicExpand
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Exendin-4 increases bone mineral density in type 2 diabetic OLETF rats potentially through the down-regulation of SOST/sclerostin in osteocytes.
AIM Glucagon-like peptide-1 (GLP-1) receptor participates in the control of bone resorption in GLP-1 knockout mice. Also, GLP-1 induces an insulin- and parathyroid hormone-independent osteogenicExpand
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Arctigenin blocks the unfolded protein response and shows therapeutic antitumor activity
Cancer cells in poorly vascularized solid tumors are constantly or intermittently exposed to stressful microenvironments, including glucose deprivation, hypoxia, and other forms of nutrientExpand
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Stretchable, Transparent Electrodes as Wearable Heaters Using Nanotrough Networks of Metallic Glasses with Superior Mechanical Properties and Thermal Stability.
Mechanical robustness, electrical and chemical reliabilities of devices against large deformations such as bending and stretching have become the key metrics for rapidly emerging wearableExpand
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Adhesion of nano-sized particles to the surface of bacteria: mechanistic study with the extended DLVO theory.
Due to the increasing production and application of nanoparticles, their release into the environment would be inevitable, which requires a better understanding of their fate in the environment. WhenExpand
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Fundamental differences in mechanical behavior between two types of crystals at the nanoscale.
We present differences in the mechanical behavior of nanoscale gold and molybdenum single crystals. A significant strength increase is observed as the size is reduced to 100 nm. Both nanocrystalsExpand
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Optimum definition of true strain beneath a spherical indenter for deriving indentation flow curves
Several methods have been suggested for deriving indentation flow curves using the instrumented indentation technique, in which true stress and true strain are defined with indentation parameters.Expand
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