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Voltage-sensor activation with a tarantula toxin as cargo
The opening and closing of voltage-activated Na+, Ca2+ and K+ (Kv) channels underlies electrical and chemical signalling throughout biology, yet the structural basis of voltage sensing is unknown.Expand
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Interactions between lipids and voltage sensor paddles detected with tarantula toxins
Voltage-activated ion channels open and close in response to changes in voltage, a property that is essential for generating nerve impulses. Studies on voltage-activated potassium (Kv) channels showExpand
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Portability of paddle motif function and pharmacology in voltage sensors
Voltage-sensing domains enable membrane proteins to sense and react to changes in membrane voltage. Although identifiable S1–S4 voltage-sensing domains are found in an array of conventional ionExpand
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Identification of Farnesyl Pyrophosphate and N-Arachidonylglycine as Endogenous Ligands for GPR92*
A series of small compounds acting at the orphan G protein-coupled receptor GPR92 were screened using a signaling pathway-specific reporter assay system. Lipid-derived molecules including farnesylExpand
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Complexation of Metal Ions with Humic Acid: Metal Ion Charge Neutralization Model
The humic acid complexation reaction presented in this work is based on the concept of metal ion charge neutralization upon complexation to humic acid functional groups. Experimental results from theExpand
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The Novel Cellular Mechanism of Human 5-HT6 Receptor through an Interaction with Fyn*
The human 5-HT6 receptor (5-HT6R) is one of the latest cloned receptors among the known 5-HT receptors. Its abundant distribution in the limbic region, which participates in the control of mood andExpand
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Passage of chronic wasting disease prion into transgenic mice expressing Rocky Mountain elk (Cervus elaphus nelsoni) PrPC.
Chronic wasting disease (CWD) of elk (Cervus elaphus nelsoni) and mule deer (Odocoileus hemionus) is one of three naturally occurring forms of prion disease, the others being Creutzfeldt-JakobExpand
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Clinical Characteristics of Primary Epiploic Appendagitis
Purpose Primary epiploic appendagitis (PEA) is a rare cause of an acute abdomen. It can be clinically misdiagnosed as either diverticulitis or appendicitis on clinical examination because theExpand
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Molecular Surface of Tarantula Toxins Interacting with Voltage Sensors in Kv Channels
The venom from spiders, scorpions, and sea anemone contain a rich diversity of protein toxins that interact with ion channel voltage sensors. Although atomic structures have been solved for many ofExpand
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Humic colloid-borne natural polyvalent metal ions: dissociation experiment.
The natural association nature of the humic colloid-borne trace elements is investigated. Rare earth elements (REE) Th and U are chosen as naturally occurring representatives and chemical homologuesExpand
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