• Publications
  • Influence
Association between arterial hyperoxia following resuscitation from cardiac arrest and in-hospital mortality.
CONTEXT Laboratory investigations suggest that exposure to hyperoxia after resuscitation from cardiac arrest may worsen anoxic brain injury; however, clinical data are lacking. OBJECTIVE To testExpand
  • 661
  • 14
  • PDF
Significance of arterial hypotension after resuscitation from cardiac arrest*
Objective:Expert guidelines advocate hemodynamic optimization after return of spontaneous circulation (ROSC) from cardiac arrest despite a lack of empirical data on prevalence of post-ROSCExpand
  • 169
  • 6
Translating research to clinical practice: a 1-year experience with implementing early goal-directed therapy for septic shock in the emergency department.
OBJECTIVE Early goal-directed therapy (EGDT) has been shown to decrease mortality in patients with severe sepsis and septic shock. Consensus guidelines now advocate EGDT for the first 6 h of sepsisExpand
  • 219
  • 5
Association Between Postresuscitation Partial Pressure of Arterial Carbon Dioxide and Neurological Outcome in Patients With Post–Cardiac Arrest Syndrome
Background— Partial pressure of arterial CO2 (PaCO2) is a regulator of cerebral blood flow after brain injury. Recent guidelines for the management of cardiac arrest recommend maintaining PaCO2 at 40Expand
  • 140
  • 4
Association between initial prescribed minute ventilation and post-resuscitation partial pressure of arterial carbon dioxide in patients with post-cardiac arrest syndrome
AbstractBackgroundPost-cardiac arrest hypocapnia/hypercapnia have been associated with poor neurological outcome. However, the impact of arterial carbon dioxide (CO2) derangements during theExpand
  • 30
  • 4
Multiple Organ Dysfunction After Return of Spontaneous Circulation in Postcardiac Arrest Syndrome
Objectives:Recent guidelines for the treatment of postcardiac arrest syndrome recommend optimization of vital organ perfusion after return of spontaneous circulation to reduce the risk ofExpand
  • 104
  • 3
Relationship Between Supranormal Oxygen Tension and Outcome After Resuscitation From Cardiac Arrest
Background— Laboratory and recent clinical data suggest that hyperoxemia after resuscitation from cardiac arrest is harmful; however, it remains unclear if the risk of adverse outcome is a thresholdExpand
  • 258
  • 2
  • PDF
Pediatric Post-Cardiac Arrest Care: A Scientific Statement From the American Heart Association.
Successful resuscitation from cardiac arrest results in a post-cardiac arrest syndrome, which can evolve in the days to weeks after return of sustained circulation. The components of post-cardiacExpand
  • 25
  • 2
  • PDF
Association between chest compression rates and clinical outcomes following in-hospital cardiac arrest at an academic tertiary hospital.
AIMS Recent guidelines for management of cardiac arrest recommend chest compression rates of 100-120 compressions/min. However, animal studies have found cardiac output to increase with rates up toExpand
  • 23
  • 2
Early arterial hypotension is common in the post-cardiac arrest syndrome and associated with increased in-hospital mortality.
AIM After return of spontaneous circulation (ROSC) from cardiac arrest, profound myocardial stunning and systemic inflammation may cause hemodynamic alterations; however, the prevalence of post-ROSCExpand
  • 103
  • 1