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Enhanced Macrophage Uptake of Low Density Lipoprotein after Self‐Aggregation
These studies show that self-aggregation of LDL markedly enhances Its uptake by macrophages, probably by phagocytosis and at least, In part, via the LDL receptor. Expand
Macrophage-derived foam cells freshly isolated from rabbit atherosclerotic lesions degrade modified lipoproteins, promote oxidation of low-density lipoproteins, and contain oxidation-specific
Data provide direct evidence that arterial wall macrophages express modified LDL receptors in vivo, contain epitopes found in oxidized-LDL and are capable of oxidizing LDL even when maximally loaded with cholesterol. Expand
Feasibility of using an oleate-rich diet to reduce the susceptibility of low-density lipoprotein to oxidative modification in humans.
The feasibility of altering the diet in a way that will not raise LDL cholesterol concentrations and yet will decrease the susceptibility of LDL to oxidative modification is demonstrated. Expand
Low density lipoprotein rich in oleic acid is protected against oxidative modification: implications for dietary prevention of atherosclerosis.
The results suggest that diets sufficiently enriched in oleic acid, in addition to their LDL-lowering effect, may slow the progression of atherosclerosis by generating LDL that is highly resistant to oxidative modification. Expand
Stimulation of rat liver phosphorylase kinase by micromolar concentrations of Ca2+
The results presented below show that phosphorylase kinase from rat liver requires Ca*+ for optimal activity and was inhibited 75% by 0.2 mM EGTA, which effectively blocked phosphatase activity. Expand
Reversible protein kinase activation of hormone-sensitive lipase from chicken adipose tissue.
Hormone-sensitive lipase partially purified from adipose tissue of laying hens was markedly activated by cyclic AMP-dependent protein kinase, indicating that the physiological hormone-induced activation is probably similar to or identical with theprotein kinase activation demonstrated in the cell-free preparations. Expand
Isoenzymes of adenylate kinase in human tissue.
Abstract A study of the isoenzymes of adenylate kinases (ATP:AMP phosphotransferases EC from several tissues of human and rabbit indicated that there is a minimum of two sets of isoenzymesExpand
Hormone-sensitive lipase in differentiated 3T3-L1 cells and its activation by cyclic AMP-dependent protein kinase.
Hormone-sensitive lipase, the most characteristic and functionally important enzyme of adipose tissue, has been characterized in differentiated 3T3-L1 cells and should be a valuable model system in which to study regulation of hormone-sensitivelipase, particularly its long-term regulation. Expand
Prevention of low density lipoprotein aggregation by high density lipoprotein or apolipoprotein A-I.
It is shown that LDL self-aggregation is strongly inhibited (80-95%) by the presence of high density lipoprotein (HDL) or apolipoprotein (apo) A-I, and that apoA-I is able to interact with the exposed hydrophobic domains of LDL and thus block the intermolecular interactions that cause aggregation. Expand