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Syntheses of 1-, 2-, 3-, 4-, 6-, 9-, and 10-hydroxy-7,12-dimethylbenz[a]anthracenes
Atromentin, anticoagulant from Hydnellum diabolus.
- J. Khanna, M. Malone, K. Euler, L. Brady
- Chemistry, Medicine
- Journal of pharmaceutical sciences
- 1 July 1965
Gross screening revealed that Hydnellum diabolus Banker contained a parenterally effective anticoagulant, while H. aurantiacum , H. caeruleum , and Hydnum laevigatum lacked activity. A 70 per cent… Expand
Chromatographie and pharmacologic evaluation of some toxic Galerina species.
Agents acting on the central nervous system. X. 1-Substituted 3-phenyl-2,3,4,5-tetrahydro-1H-1-benzazepines.
Synthesis and antimicrobial activity of novel thiazolidinones
A novel synthesis of thiazolidine-2-thione and thiazolidin-2-one derivatives is described with the iodo-cyclothiocarbamation reaction as the key step for the heterocyclic ring formation. This new… Expand
N-alkylation of secondary amines with esters and lithium alanate
A Cost-Efficient Synthesis of Simvastatin via High-Conversion Methylation of an Alkoxide Ester Enolate
A cost-efficient synthesis of simvastatin (2), starting from mevinolin (lovastatin) (1a) or its precursor mevinolinic acid (1b), is reported. This synthesis involves the use of a new intermediate,… Expand
Synthesis of trans -2-[ N -(2-Hydroxy-1,2,3,4-tetrahydronaphthalene-1-yl)]iminothiazolidine and Related Compounds - A New Class of Antidepressants
Antiparasitic and antidepressant activities exhibited by tetramisole ( I ) and its enantiomers prompted the study of its structural analogs trans… Expand
Phenethylamine in a rigid framework : synthesis, stereochemistry and reactions of cis and trans-4-amino-2,3,4,5-tetrahydro- 1-benzoxepin-5-ols and their derivatives
Abstract cis - and trans - amino alcohols 1a and 2a and their derivatives have been synthesised and their stereochemistry studied. Stereochemical studies have shown that cis -isomer is… Expand