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Darbepoetin alfa given every 1 or 2 weeks alleviates anaemia associated with cancer chemotherapy
In part A of this study, patients were randomised to cohorts receiving darbepoetin alfa at doses of 0.5 to 8.0 m.c.g. kg−1 wk−1 or to a control group receiving epoetin alfa at an initial dose of 150Expand
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A dose-finding and safety study of novel erythropoiesis stimulating protein (NESP) for the treatment of anaemia in patients receiving multicycle chemotherapy
Darbepoetin alfa is a novel erythropoiesis stimulating protein (NESP), which stimulates erythropoiesis by the same mechanism as recombinant human erythropoietin (rHuEPO). NESP has been shown to beExpand
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Heterotypic FcγR Clusters Evoke a Synergistic Ca2+ Response in Human Neutrophils (*)
Both Fcγ receptors on human neutrophils (FcγRIIa and FcγRIIIb) are capable of initiating signal transduction after multivalent cross-linking. However, immune complexes most likely activateExpand
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Leukocyte differentials predict short-term clinical outcome following antipsychotic treatment in schizophrenia
BACKGROUND The majority of patients with schizophrenia and many of their unaffected siblings exhibit a relative granulocytosis and lymphopenia. To characterize these abnormalities better, we examinedExpand
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Immediate termination of intractable vomiting induced by cisplatin combination chemotherapy using an intensive five-drug antiemetic regimen.
A five-drug parenteral antiemetic regimen was administered to 17 patients experiencing intractable vomiting following treatment with cisplatin-containing combination chemotherapy. The five-drugExpand
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Substrate and product specificity of Arthrobacter sialophilus neuraminidase.
Arthrobacter sialophilus neuraminidase catalyzes the hydrolysis of N-acetylneuraminyl-alpha-oxygen, nitrogen, and azido glycosides. The most effective of those substrates examined wasExpand
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Anaphylactoid Reactions with Intraperitoneal Cisplatin
Objective: To report the occurrence of anaphylactoid reactions to intraperitoneal cisplatin in 3 patients. Case Summaries: While conducting a protocol evaluating the efficacy of intraperitonealExpand
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Cortical blindness and seizures possibly related to cisplatin, vinblastine, and bleomycin treatment of ovarian dysgerminoma.
Ovarian dysgerminoma is the most common ovarian malignancy in young women. Conservative treatment is indicated in the reproductive-age woman who wishes to preserve childbearing capacity. This caseExpand
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