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Efficient method for the preparation of peptoids [oligo(N-substituted glycines)] by submonomer solid-phase synthesis
Oligomers of N-substituted glycines, or “peptoids“, represent a new class of polymers (Figure 1) that are not found in nature, but are synthetically accessible and have been shown to possessExpand
Proteolytic studies of homologous peptide and N-substituted glycine peptoid oligomers
Abstract Homologous L-amino acid, D-amino acid, and parallel and anit-parallel (retro) sequence N-substituted glycine peptide and peptoid oligomers were prepared and incubated with proteases fromExpand
Comparison of the proteolytic susceptibilities of homologous L‐amino acid, D‐amino acid, and N‐substituted glycine peptide and peptoid oligomers
A series of homologous L‐amino acid, D‐amino acid, and both parallel and anti‐parallel (retro) sequence N‐substituted glycine peptide and peptoid oligomers were prepared and incubated with a seriesExpand
Discovery of nanomolar ligands for 7-transmembrane G-protein-coupled receptors from a diverse N-(substituted)glycine peptoid library.
Screening a diverse, combinatorial library of ca. 5000 synthetic dimer and trimer N-(substituted)glycine "peptides" yielded novel, high-affinity ligands for 7-transmembrane G-protein-coupledExpand
Simplified methods for construction, assessment and rapid screening of peptide libraries in bacteriophage.
TLDR
Immunological screening, an efficient technique for the rapid identification of putative binding bacteriophage, is described and a novel method for evaluating the genetic diversity of bacteriophile libraries based on colony hybridization with partially degenerate oligonucleotides has been developed. Expand
A simple method for the preparation of 123I and 125I labeled iodobenzodiazepines
Abstract The tributyltin derivative of the benzodiazepine antagonist ethyl 7-iodo-5,6-dihydro-5-methyl-6-oxo-4H-imidazo[1,5-a] [1,4]benzodiazepine-3-carboxylate (Ro 16-0154) was synthesized by aExpand
Nmr Structural Characterization of Oligo-N-Substituted Glycine Lead Compounds from a Combinatorial Library
TLDR
Solution NMR studies indicate that although CHIR-2279 and CHir-4531 have identical backbones and termini, and very similar side chains, they do not display the same solution conformational characteristics. Expand
Identification of highest-affinity ligands by affinity selection from equimolar peptide mixtures generated by robotic synthesis
A fully automated peptide synthesizer has been constructed that is capable of the simultaneous synthesis of up to 36 individual peptides and the synthesis of equimolar peptide mixtures. TheExpand
Design, construction and application of a fully automated equimolar peptide mixture synthesizer.
A fully automated peptide synthesizer has been constructed that is capable of the synthesis of equimolar peptide mixtures and the simultaneous synthesis of 36 individual peptides. The synthesizer wasExpand
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