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Monoacylglycerol Lipase Activity Is a Critical Modulator of the Tone and Integrity of the Endocannabinoid System
These findings provide the first genetic in vivo evidence that MAGL is the major regulator of 2-AG levels and signaling and reveal a pivotal role for 2- AG in modulating CB1 receptor sensitization and endocannabinoid tone.
Species‐specific in vitro pharmacological effects of the cannabinoid receptor 2 (CB2) selective ligand AM1241 and its resolved enantiomers
The purpose of the studies was to provide a characterization of R,S‐AM1241 and its resolved enantiomers in vitro and in vivo.
Peripheral neuropathic pain: a mechanism-related organizing principle based on sensory profiles
A new approach of subgrouping patients with peripheral neuropathic pain of different etiologies according to intrinsic sensory profiles is presented, which may be related to pathophysiological mechanisms and may be useful in clinical trial design to enrich the study population for treatment responders.
Depression-like phenotype following chronic CB1 receptor antagonism
One night of total sleep deprivation promotes a state of generalized hyperalgesia: A surrogate pain model to study the relationship of insomnia and pain
Functional characterization of Narc 1, a novel proteinase related to proteinase K.
Inhibition of osteoclasts prevents cartilage loss and pain in a rat model of degenerative joint disease.
Dynamic Changes in the MicroRNA Expression Profile Reveal Multiple Regulatory Mechanisms in the Spinal Nerve Ligation Model of Neuropathic Pain
A miRNA expression profiling study of dorsal root ganglion tissue from rats four weeks post spinal nerve ligation, suggesting the potential for miRNAs to play a direct role in neuropathic pain.
Ensuring transparency and minimization of methodologic bias in preclinical pain research: PPRECISE considerations
To achieve the goal of finding effective new treatments for patients with pain, the pain field needs to deal with these challenging issues, and greater transparency of reporting should be driven by scientists, journal editors, reviewers, and grant funders.