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Chrysophaentins A-H, antibacterial bisdiarylbutene macrocycles that inhibit the bacterial cell division protein FtsZ.
Eight new antimicrobial natural products named chrysophaentins A-H belonging to a new structural class have been isolated from the marine chrysophyte alga Chrysophaeum taylori and are characterized by the presence of two polyhalogenated, polyoxygenated omega,omega'-diarylbutene units connected by two ether bonds to form the suite of macrocyclic natural products. Expand
Acrolein-derived DNA adduct formation in human colon cancer cells: its role in apoptosis induction by docosahexaenoic acid.
Results demonstrate the parallel relationships between Acr-dG level and apoptosis in HT-29 cells, suggesting that the formation of Acr -dG in cellular DNA may contribute to apoptosis induced by DHA. Expand
Characterization of an Unconventional Rhodopsin from the Freshwater Actinobacterium Rhodoluna lacicola
The results suggest that in some organisms, the actinorhodopsin gene is constitutively expressed, but r Rhodopsin-based light capture may require cofactors obtained from the environment, as well as indicating that photoheterotrophy in this organism and others may need cofactor obtained fromThe environment. Expand
Celebesides A-C and theopapuamides B-D, depsipeptides from an Indonesian sponge that inhibit HIV-1 entry.
Six new depsipeptides belonging to two different structural classes, termed celebesides A-C and theopapuamides B-D, have been isolated from the marine sponge Siliquariaspongia mirabilis using extensive 2D NMR and ESI-MS/MS techniques. Expand
Mutremdamide A and koshikamides C-H, peptide inhibitors of HIV-1 entry from different Theonella species.
The combination of mutremdamide A, koshikamides, and theonellamides appears to define a new Theonella chemotype that can be found in deeper waters. Expand
Chrysophaentins are competitive inhibitors of FtsZ and inhibit Z-ring formation in live bacteria.
These studies describe unique examples of nonnucleotide, competitive FtsZ inhibitors that disrupt FTSZ in vivo, together with a model system that should be useful for in vivo testing of Ftsz inhibitor leads that have been identified through in vitro screens but are unable to penetrate the Gram-negative outer membrane. Expand
Motualevic acids A-F, antimicrobial acids from the sponge Siliquariaspongia sp.
Seven new antibacterials, motualevic acids A-F (1-6) and (4E)-(R)-antazirine (7), have been isolated from the marine sponge Siliquariaspongia sp. and their structures elucidated by spectroscopicExpand
Iron oxidation by a fused cytochrome-porin common to diverse iron-oxidizing bacteria
The iron oxidase function of heterologously expressed Cyc2 from a neutrophilic iron-oxidizer Mariprofundus ferrooxydans PV-1 is investigated and predicted that the monoheme cytochrome CyC2 specifically oxidizes dissolved Fe2+, in contrast to multiheme iron oxidases, which may oxidize solid Fe(II). Expand
Light Modulates the Physiology of Nonphototrophic Actinobacteria
The ability of Actinobacteria to coordinate organic carbon uptake and utilization with production of photosynthate enables them to grow more efficiently in the daytime, and it potentially gives them a competitive advantage over heterotrophs that constitutively produce carbohydrate transporters, which is energetically costly. Expand