Multiple receptors for dopamine
- J. Kebabian, D. Calne
- Biology, ChemistryNature
- 1 January 1979
Pharmacological and biochemical criteria can be used to separate those dopamine receptors which are linked to the enzyme adenylyl cyclase and those which are not.
Opposing roles for D-1 and D-2 dopamine receptors in efflux of cyclic AMP from rat neostriatum
- J. C. Stoof, J. Kebabian
- BiologyNature
- 26 November 1981
It is shown here that stimulation of the D-2 receptor is followed by a reduction in cyclic AMP formation induced by V stimulation with D-1 agonists.
The Sigma-RBI handbook of receptor classification and signal transduction
- K. Watling, J. Kebabian, J. Neumeyer
- Chemistry
- 1995
Dopamine-sensitive adenylate cyclase in caudate nucleus of rat brain, and its similarity to the "dopamine receptor".
- J. Kebabian, G. Petzold, P. Greengard
- Biology, PsychologyProceedings of the National Academy of Sciences…
- 1 August 1972
The results suggest that dopamine-sensitive adenylate cyclase may be the receptor for dopamine in mammalian brain and should facilitate the search for new therapeutic agents useful in the treatment of extrapyramidal diseases.
Two dopamine receptors: biochemistry, physiology and pharmacology.
- J. C. Stoof, J. Kebabian
- Biology, MedicineLife Science
- 3 December 1984
Dopamine-Sensitive Adenyl Cyclase: Possible Role in Synaptic Transmission
- J. Kebabian, P. Greengard
- BiologyScience
- 24 December 1971
The results suggest that the physiological effects of dopamine in the ganglion, and possibly elsewhere in the nervous system, may be mediated by stimulating the synthesis of adenosine 3',5'-monophosphate.
Dopamine-sensitive adenylate cyclase in mammalian brain: a possible site of action of antipsychotic drugs.
- Y. Clement‐Cormier, J. Kebabian, G. Petzold, P. Greengard
- Biology, PsychologyProceedings of the National Academy of Sciences…
- 1 April 1974
The results raise the possibility that the therapeutic effects, as well as the extrapyramidal side effects, of these antipsychotic agents may be attributable, at least in part, to their ability to block the activation by dopamine of specific dopamine-sensitive adenylate cyclases in the human brain.
A-77636: a potent and selective dopamine D1 receptor agonist with antiparkinsonian activity in marmosets.
- J. Kebabian, D. R. Britton, M. Williams
- BiologyEuropean Journal of Pharmacology
- 15 December 1992
Evidence that LY-141865 specifically stimulates the D-2 dopamine receptor
- K. Tsuruta, E. Frey, C. Grewe, T. Cote, R. Eskay, J. Kebabian
- Biology, MedicineNature
- 30 July 1981
It is reported here that one of these ergoline analogues, LY-141865 or ‘38, R = pro’21, stimulates the D-2 receptor in the intermediate lobe (IL) of the rat pituitary gland but does not interact with theD-1 receptor in carp retina.
Pharmacological and Biochemical Evidence for the Existence of Two Categories of Dopamine Receptor
- J. Kebabian, M. Beaulieu, Y. Itoh
- BiologyCanadian Journal of Neurological Sciences…
- 1 February 1984
Evidence supporting the validity of the ‘two dopamine receptor’ hypothesis is presented and binding assays demonstrating two affinity states for the D-1 and the D -2 receptors are briefly discussed.
...
...